Il Cochrane PEC ha selezionato le Revisioni Cochrane dedicate alla emergenza territoriale e alla medicina d’urgenza da Gennaio 2012 a Giugno 2023 :
Revisioni Cochrane sull’ Emergenza
| Status | Stage |
|---|---|
- A breathing intervention for shortness of breath due to heart failure
- A comparison of a local anaesthetic injection below the collarbone with other injection techniques for providing anaesthesia of the lower arm
- A gentler form of mechanical breathing for people affected by severe lung failure
- A single beta lactam antibiotic versus a beta lactam-aminoglycoside combination for patients with severe infection
- A spray containing ipratropium bromide administered into the nose to treat common cold symptoms
- Accuracy of prehospital stroke scales to identify people with stroke or transient ischemic attack (TIA)
- Acetaminophen (also called paracetamol) for the common cold in adults
- Acetylcysteine and carbocysteine to treat acute upper and lower respiratory tract infections in children without chronic broncho-pulmonary disease
- Active compression-decompression using a hand-held device for emergency heart massage
- Acupuncture for acute management and rehabilitation of traumatic brain injury
- Acupuncture for acute stroke
- Acupuncture for sudden-onset ankle sprains in adults
- Addition of intravenous beta2-agonists to inhaled beta2-agonists for acute asthma
- Adenosine versus intravenous calcium channel antagonists for tachycardia in adults
- Adjustment of antimicrobial agents for adults with sepsis, severe sepsis or septic shock
- Administering antimalarial drugs to prevent malaria in infants
- Adrenaline and vasopressin for cardiac arrest
- Adrenaline auto-injectors for the treatment of anaphylaxis in the community
- Adult patient access to electronic health records
- Advanced training in trauma life support for ambulance crews
- Advanced training in trauma life support for hospital staff
- Airway clearance techniques for chronic obstructive pulmonary disease
- Airway clearance techniques in bronchiectasis
- Alcohol has a biphasic effect on blood pressure and increases heart rate
- Alginate dressings for healing foot ulcers in people with diabetes mellitus
- Alpha-blockers for ureteral stones in adult patients with symptoms of stone disease
- Alternating and combined antipyretics for treatment of fever in children
- Alternative dosing strategies for intravenous antibiotics to treat severe infections
- Alternative or additional agents to platelet transfusions to prevent bleeding in people with blood cancers receiving intensive treatment
- Amantadine and rimantadine to prevent and treat influenza A in children and the elderly
- Aminophylline for cardiac arrest
- Anaesthesia or analgesia during the manual removal of a retained placenta
- Anaesthetic drugs for cardioversion
- Anti-D administration after spontaneous miscarriage for preventing Rhesus alloimmunisation
- Anti-inflammatory drugs for acute low back pain
- Anti-leukotriene agents compared to inhaled corticosteroids for people with asthma
- Antiarrhythmics for maintaining sinus rhythm (normal heartbeat) after reversing atrial fibrillation (correcting an irregular heartbeat)
- Antibiotic drugs for treating skin and soft tissue infections
- Antibiotic prophylaxis for short-term catheter bladder drainage in adults
- Antibiotic therapy for Clostridium difficile-associated diarrhoea in adults
- Antibiotic therapy for preventing infections in people with acute stroke
- Antibiotic therapy for the treatment of methicillin-resistant Staphylococcus aureus (MRSA)-infected or colonised non surgical wounds
- Antibiotic treatment for asymptomatic bacteriuria
- Antibiotic treatment for people with acute bronchitis
- Antibiotic treatment for spontaneous bacterial peritonitis in people with advanced liver disease
- Antibiotic treatment for Stenotrophomonas maltophilia in people with cystic fibrosis
- Antibiotic use for severe toothache (irreversible pulpitis)
- Antibiotics at the time of removal of a central line to reduce complications in newborn infants
- Antibiotics for acute middle ear infection (acute otitis media) in children
- Antibiotics for adults and children with sore throats
- Antibiotics for bronchiolitis in children under two years of age
- Antibiotics for common respiratory infections with unclear causes and undifferentiated symptoms in children up to five years of age
- Antibiotics for community-acquired pneumonia in adolescent and adult outpatients
- Antibiotics for covert bacteriuria in children
- Antibiotics for injuries to the abdomen that break through the skin: which antibiotics are effective, and for how long should they be taken?
- Antibiotics for lower urinary tract infection in children
- Antibiotics for mastitis in breastfeeding women
- Antibiotics for non-typhoidal Salmonella diarrhoea
- Antibiotics for otitis media with effusion ('glue ear') in children
- Antibiotics for persistent cough or wheeze following acute bronchiolitis in children
- Antibiotics for preventing meningococcal infections
- Antibiotics for rupture of membranes when a pregnant women is at or near term but not in labour
- Antibiotics for sinus infection of short duration in adults
- Antibiotics for the common cold, an infection of the upper respiratory tract
- Antibiotics for the treatment of leptospirosis
- Antibiotics for treating acute chest syndrome in people with sickle cell disease
- Antibiotics for treating bacterial vaginosis in pregnancy
- Antibiotics for treating cholera
- Antibiotics for treating human brucellosis
- Antibiotics for treating osteomyelitis in people with sickle cell disease
- Antibiotics for treating pneumonia caught outside of hospital or care homes in people with sickle cell disease
- Antibiotics for uncomplicated diverticulitis
- Antibiotics to prevent bacterial infections due to chemotherapy in cancer patients with a low white blood cell count and no fever
- Antibiotics to prevent burn wounds becoming infected
- Antibiotics to prevent infection of the brain coverings (meningitis) in patients with basilar skull fracture
- Antibiotics to treat adults with acute laryngitis
- Antibiotics to treat foot infections in people with diabetes
- Antibiotics to treat respiratory infections caused by the bacteria Mycoplasma pneumoniae in children
- Antibiotics to treat suspected cases meningitis due to infection with meningococcus before confirmation of diagnosis
- Anticholinergic therapy for acute asthma in children
- Anticoagulant treatment for subsegmental pulmonary embolism
- Anticonvulsant therapy for status epilepticus
- Antidepressants for agitation and psychosis in dementia
- Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage
- Antiepileptic drugs for the primary and secondary prevention of seizures in viral encephalitis
- Antiepileptic drugs versus no treatment or placebo for children with benign epilepsy with centro temporal spikes
- Antifibrinolytic amino acids for upper gastrointestinal bleeding in people with acute or chronic liver disease
- Antifibrinolytic drugs to treat heavy bleeding after childbirth
- Antifibrinolytic therapy to reduce haemoptysis
- Antifibrinolytics (such as tranexamic acid) for treatment of heavy menstrual bleeding
- Antifibrinolytics (tranexamic acid and epsilon-aminocaproic acid) to prevent bleeding in people with low platelets due to bone marrow failure
- Antihistamines for the common cold
- Antihistamines to prevent and treat motion sickness
- Antiplatelet agents and anticoagulants for high blood pressure (hypertension)
- Antiplatelet agents for preventing pre-eclampsia and its complications
- Antiplatelet versus anticoagulation treatment for patients with heart failure in sinus rhythm
- Antipsychotic drugs for elderly people with late-onset schizophrenia
- Antipyretic measures for treating fever in malaria
- Antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV in high-risk individuals
- Antiseptics for Burns
- Antispasmodics for labour
- Antithrombin III for critically ill patients
- Antiviral drugs for sudden hearing loss (without known cause)
- Antiviral medication for the treatment of infectious mononucleosis (glandular fever)
- Antiviral treatment for Bell's palsy
- Approaches to guiding oxygen therapy in adult intensive care patients with acute respiratory distress syndrome
- Are anti-blood clotting drugs beneficial for people with chronic kidney disease?
- Are antibiotics a safe and effective additional treatment for asthma exacerbations?
- Are antibiotics an effective treatment for COVID-19 and do they cause unwanted effects?
- Are antibiotics beneficial for flare-ups of chronic obstructive pulmonary disease?
- Are corticosteroids (anti-inflammatory medicines) given orally or by injection an effective treatment for people with COVID-19?
- Are digital contact tracing technologies effective during infectious disease outbreaks?
- Are direct oral anticoagulants (a type of 'blood thinner') better than conventional anticoagulation for treating people with a blood clot in a deep vein?
- Are direct oral anticoagulants (a type of 'blood thinner') better than traditional anticoagulants for treating a pulmonary embolism (a blood clot in the lung)?
- Are inflatable sleeves and medication effective to prevent deep vein thrombosis and pulmonary embolism after surgery?
- Are inhaled anticholinergics added to β2-agonists beneficial in children hospitalised with acute asthma?
- Are inhaled corticosteroids an effective treatment for people with mild COVID-19?
- Are interventions to improve clinical incidence reporting effective?
- Are laboratory-made COVID-19-specific monoclonal antibodies effective to prevent COVID-19 in adults?
- Are laboratory-made, COVID-19-specific monoclonal antibodies an effective treatment for COVID-19?
- Are medicines that block interleukin‐1 (a protein involved in immune responses) effective treatments for COVID‐19 and do they cause unwanted effects?
- Are medicines that delay the start of labour (tocolytics) effective for delaying preterm birth?
- Are non-steroidal anti-inflammatory drugs safe and effective for treating heavy menstrual bleeding?
- Are shorter courses of systemic steroids as effective as conventional longer courses in the treatment of patients with flare-ups of COPD?
- Are stem cells taken from a person's bone marrow and delivered to their heart a safe and effective treatment following a heart attack?
- Are systemic Janus kinase inhibitors an effective treatment for people with COVID-19?
- Are tiotropium plus combination inhalers better than tiotropium or combination inhalers alone for the treatment of COPD?
- Aripiprazole alone or in combination with other drugs for treating the acute mania phase of bipolar disorder
- Artemether injection for treating people with severe malaria
- Artemisinin-based combination therapy (ACT) for treating non-severe malaria due to Plasmodium vivax
- Artemisinin-naphthoquine for treating uncomplicated Plasmodium falciparum malaria
- Artesunate reduces death from severe malaria
- Aspiration of the elbow joint for treating radial head fractures
- Aspirin with or without an antiemetic for acute migraine headaches in adults
- Aspirin, steroid and non-steroidal anti-inflammatory drugs use for treating Alzheimer's disease
- Asthma reliever inhalers (beta2-agonists) used for exercise-induced asthma and exercise-induced bronchoconstriction
- Audio-visual presentation of information used in the informed consent process for people considering entering clinical trials
- Audit and feedback: effects on professional practice
- Automated monitoring for the early detection of sepsis in patients receiving care in intensive care units
- Azithromycin for acute lower respiratory tract infections
- Azithromycin versus penicillin G benzathine for early syphilis
- B-type natriuretic peptide-guided treatment for heart failure patients
- Back schools for acute and subacute non-specific low-back pain
- Baclofen for alcohol withdrawal syndrome
- Balanced crystalloid solutions versus 0.9% saline for severely dehydrated children with acute diarrhoea
- Band ligation versus no intervention for primary prevention of upper gastrointestinal bleeding in people with cirrhosis and oesophageal varices
- Banding ligation versus beta-blockers for primary prevention in oesophageal varices in adults
- Barbiturate drugs for people with traumatic brain injury
- Baseline scores of Mini-Mental State examination (MMSE) for early prediction of developing dementia in people with mild cognitive impairments (MCI)
- Bathing critically ill patients with chlorhexidine to prevent hospital-acquired infections
- Benefits and harms of ablation for people with non-paroxysmal atrial fibrillation
- Benefits and harms of drug-eluting versus bare-metal stents in people with acute coronary syndrome
- Benefits of antihypertensive drugs for mild hypertension are unclear
- Benzodiazepines alone or in combination with antipsychotic drugs for acute psychosis
- Benzodiazepines for panic disorder in adults
- Benzodiazepines for schizophrenia
- Best position for newborns who need assisted ventilation
- Beta-blockers for children with congestive heart failure
- Beta-blockers for hypertension
- Beta-blockers for preventing stroke recurrence
- Beta-blockers versus placebo or no intervention for patients with suspected or diagnosed myocardial infarction
- Beta2-agonist drugs for treating cough or a clinical diagnosis of acute bronchitis
- Betahistine for symptoms of vertigo
- Bias due to selective inclusion and reporting of outcomes and analyses in systematic reviews of randomised trials of healthcare interventions
- Blood and urine tests for the diagnosis of acute pancreatitis (sudden inflammation of pancreas)
- Blood pressure targets in people with cardiovascular disease
- Blood tests for the diagnosis of pancreatic necrosis (pancreatic destruction due to inflammation of pancreas)
- Blood thinners for the initial treatment of blood clots in people with cancer
- Blood transfusions for people with sickle cell disease before they undergo surgery
- Blood transfusions for treating acute chest syndrome in people with sickle cell disease
- Blood-clot promoting drugs for acute traumatic injury
- Body position and intake of fluids for preventing headache after a lumbar puncture
- Branched-chain amino acids improve symptoms of hepatic encephalopathy
- Bronchodilators for bronchiolitis for infants with first-time wheezing
- Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children
- Buflomedil for acute ischaemic stroke
- Buprenorphine for managing opioid withdrawal
- Caffeine as an analgesic adjuvant for acute pain in adults
- Calcitonin used to treat metastatic bone pain
- Calcium antagonists as an add-on therapy for drug-resistant epilepsy
- Calcium antagonists for acute ischemic stroke
- Calcium channel blockers for inhibiting preterm labour and birth
- Calcium channel blockers versus other classes of drugs for hypertension
- Can breathing support using continuous positive airway pressure (CPAP), given within the first hour of life, prevent death and illness in premature babies?
- Can exhaled nitric oxide be used to adjust asthma medications in children with asthma?
- Can international travel-related control measures contain the spread of the COVID-19 pandemic?
- Can mefloquine prevent malaria during travel to areas where the disease is widespread?
- Can tests for inflammation help doctors decide whether to use antibiotics for airway infections?
- Carbetocin for preventing postpartum haemorrhage
- Central venous access sites to prevent venous blood clots, blood vessel narrowing, and infection
- Central venous catheter coating with antiseptics or antibiotics for reducing catheter-related infections in adults
- Cephalosporin antibiotics for the treatment of enteric fever (typhoid fever)
- Cerebrolysin for acute ischaemic stroke
- Cervical assessment by ultrasound for preventing preterm delivery
- Chances of developing blood clots for people who have COVID-19 and are taking hormonal birth control compared to people not taking hormonal birth control
- Chest physiotherapy for acute bronchiolitis in children younger than two years of age
- Chest physiotherapy for pneumonia in adults
- Chest X-rays in acute chest infections
- Chinese herbs combined with Western medicine for treating severe acute respiratory syndrome (SARS)
- Chinese medicinal herbs for influenza
- Clinical symptoms and signs for the diagnosis of Mycoplasma pneumoniae in children and adolescents with community-acquired pneumonia
- Clinical symptoms, signs and tests for identification of impending and current water-loss dehydration in older people
- Clinical tools for detecting cervical spine injury (CSI) in children with injuries
- Clonazepam add-on therapy for drug-resistant epilepsy in adults and children
- Clonazepam for neuropathic pain and fibromyalgia in adults
- Clonidine, lofexidine, and similar medications for the management of opioid withdrawal
- Clot-dissolving drugs (different doses, routes of administration and agents) for breaking down a blood clot blocking a blood vessel in the brain
- Clot-dissolving drugs for treating ischaemic stroke in the early stages
- Codeine, alone and with paracetamol (acetaminophen), for cancer pain
- Cognitive-behavioural treatments for non-cardiac chest pain
- Colchicine for treating acute gout flares
- Cold-water immersion for preventing and treating muscle soreness after exercise
- Colloids or crystalloids for fluid replacement in critically ill people
- Combinations of tocolytic drugs for inhibiting preterm labour
- Combined beta-agonists and anticholinergics compared to beta-agonists alone for adults with asthma treated in emergency departments
- Combined inhalers compared to tiotropium inhalers for the treatment of chronic obstructive pulmonary disease
- Combined inhalers versus placebo for the treatment of chronic obstructive pulmonary disease (COPD)
- Community first responders for out-of-hospital cardiac arrest in adults and children
- Comparing different types of scan (CT, MRI, bone scan) for diagnosis of clinically suspected scaphoid fractures, when initial radiographs are negative
- Comparing treatment of non-severe pneumonia, in children aged 2 to 59 months, with and without antibiotics
- Comparing two types of blood-thinning drugs, factor Xa inhibitors and vitamin K antagonists, to prevent blood clots in people with atrial fibrillation
- Comparing walk-in clinics to physician offices and emergency rooms
- Comparison of central adjudication of outcomes and onsite outcome assessment on treatment effect estimates
- Comparison of different techniques for planned opening of the trachea
- Comparison of propofol (an anaesthetic drug) with other drug options for sedating people undergoing painful procedures in emergency departments
- Comparison of the different ways of giving fluids to patients who cannot drink enough, such as patients with Ebola virus disease
- Comparison of two muscle relaxants, rocuronium and succinylcholine, to facilitate rapid sequence induction intubation
- Comparison of video-assisted and non-video-assisted devices for intubation of children
- Computed tomography angiography or magnetic resonance angiography for detecting blood vessel abnormalities in patients with intracerebral haemorrhage
- Concentrated salt solution versus other treatments to lower pressure around the brain for people with acute traumatic brain injury
- Conflicts of interest and recommendations in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews
- Conservative interventions for shaft fractures of the forearm bones in children
- CONsolidated Standards Of Reporting Trials (CONSORT) and the completeness of reporting of randomised controlled trials published in medical journals
- Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation (CPR) of non-asphyxial out-of-hospital cardiac arrest (OHCA)
- Continuous negative extrathoracic pressure or continuous positive airway pressure for children with acute respiratory failure and shortage of oxygen
- Continuous or intermittent monitoring of people with acute stroke
- Continuous positive airway pressure (CPAP) for acute bronchiolitis in children
- Continuous positive airways pressure for respiratory distress in preterm infants
- Controlled hypotension versus normotensive resuscitation strategy for people with ruptured abdominal aortic aneurysm
- Controlling high blood sugar levels with insulin in people who have had an acute ischaemic stroke
- Cooling the body after resuscitation following cardiac arrest
- Coronary artery bypass surgery performed with versus without cardiac arrest and cardiopulmonary bypass in patients with ischaemic heart disease
- Corticosteroid eye drops used in addition to standard antibiotic therapy in the treatment of bacterial keratitis
- Corticosteroids as stand-alone or add-on treatment for sore throat
- Corticosteroids for bacterial meningitis
- Corticosteroids for Bell's palsy
- Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy
- Corticosteroids for Guillain-Barré syndrome
- Corticosteroids for the management of cancer-related breathlessness in adults with cancer
- Corticosteroids for the treatment of parasitic eosinophilic meningitis
- Corticosteroids for treating dengue infection in children and adults
- Corticosteroids for treating sepsis
- Crisis intervention for people with severe mental illnesses
- Crisis interventions for people with borderline personality disorder
- Cuffed versus uncuffed endotracheal tubes for neonates
- Cuffed versus uncuffed tubes in children aged eight years and under, having general anaesthetic
- D-dimer for excluding pulmonary embolism in hospital outpatient and accident and emergency populations
- Decongestants, antihistamines and nasal irrigation for acute sinusitis in children
- Deep transverse friction massage for the treatment of lateral elbow or lateral knee tendinitis
- Delayed antibiotic prescriptions for respiratory tract infections
- Delivering clot-busting therapy before reaching hospital or in hospital to help people who are having heart attacks
- Devices with safety features for preventing percutaneous exposure injuries in healthcare staff
- Dexmedetomidine and clonidine for long-term sedation during mechanical ventilation in critically ill patients
- Diagnostic tests for assessing rotator cuff tears in people with shoulder pain for whom surgery is being considered
- Diclofenac with or without an antiemetic for acute migraine headaches in adults
- Different antibiotics for community-acquired pneumonia in otherwise healthy children younger than 18 years of age in hospital and outpatient settings
- Different antibiotics for group A streptococcal pharyngitis
- Different doses and durations of oral steroids for asthma attacks
- Different doses of platelet transfusion for preventing bleeding in people with low platelet counts due to treatment-induced bone marrow failure
- Different fluid therapy strategies for sepsis and septic shock
- Different methods of manipulation for reducing pulled elbow in young children
- Different methods of ventilation (controlling pressure vs volume) for people with acute respiratory failure due to lung injury
- Digitalis for treatment of heart failure in patients in sinus rhythm
- Direct oral anticoagulants for prevention of stroke in atrial fibrillation patients with chronic kidney disease
- Direct thrombin inhibitors compared with vitamin K antagonists in people with atrial fibrillation for preventing stroke
- Discharge planning from hospital
- Disease management programmes for heart failure
- Do antipsychotic medicines reduce agitated behaviour and psychotic symptoms in people with Alzheimer's disease and vascular dementia?
- Do blood thinners prevent blood clots in children who are treated using central lines?
- Do blood thinners prevent people who are hospitalised with COVID-19 from developing blood clots?
- Do education and training programs reduce aggressive behavior toward healthcare workers?
- Do local anaesthetic nerve blocks provide effective pain relief for adults with a hip fracture?
- Do magnesium sulfate infusions reduce the need for hospital admission in adults with acute asthma?
- Do magnesium sulfate infusions reduce the need for hospital admission in children with acute asthma?
- Do nasal decongestants used alone relieve cold symptoms?
- Do painkillers rubbed on the skin really work?
- Do people recover from exacerbations of chronic obstructive pulmonary disease (COPD) better in their own home than in the hospital emergency room?
- Do systemic corticosteroids improve treatment outcomes in flare-ups of chronic obstructive pulmonary disease?
- Do ventilators that manage the reduction of ventilator support (weaning) reduce the duration of weaning compared to strategies managed by clinicians?
- Do video-assisted instruments for inserting breathing tubes in adults work better than direct-view instruments and do they cause unwanted effects?
- Does adding antileukotriene agents to usual care when people are suffering an asthma attack in the emergency department help?
- Does an aminophylline injection in addition to bronchodilators for an asthma attack improve lung function and other outcomes or cause harm?
- Does cleaning hands with ash stop or reduce the spread of viral and bacterial infections compared with soap or other materials?
- Does heparin locking prevent blocking of central venous catheters in adults when compared to locking with normal saline?
- Does hyperbaric oxygen therapy improve outcome after heart attack?
- Does hyperbaric oxygen therapy improve the survival and quality of life in patients with traumatic brain injury?
- Does the placement of a breathing tube using video assistance (videolaryngoscopy) increase the success and safety of the procedure in newborn babies?
- Does the speed of injection make a difference in the amount of pain and bruising in people receiving heparin injections?
- Does the type of anaesthesia for recanalisation therapies for acute ischaemic stroke affect patient outcomes?
- Does using low-sodium salt substitutes (LSSS) instead of regular salt reduce blood pressure and heart disease risks, and is it safe?
- Dopamine agents for hepatic encephalopathy
- Dosage intervals of amoxicillin for the treatment of acute middle ear infection
- Dressings and securement for central venous catheters (CVCs)
- Dressings for the prevention of surgical site infection
- Dressings for treating superficial and partial thickness burns
- Drug interventions for deliberately altering blood pressure in acute stroke
- Drug management for acute tonic-clonic convulsions (fits), including convulsive status epilepticus in children
- Drug treatment for pain in Guillain-Barré syndrome
- Drug treatment for small abdominal aortic aneurysms
- Drug treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for acute Guillain Barré syndrome
- Drug treatments for pain in children and young people with life-limiting conditions
- Drug treatments that specifically target ammonia for adults with cirrhosis and hepatic encephalopathy
- Drugs for preventing headache after a lumbar puncture
- Drugs for preventing major morbidity and mortality related to blood pressure and heart rate changes associated with tracheal intubation
- Drugs for reducing iron in people with acute stroke
- Drugs for the acute treatment of migraine in children and adolescents
- Drugs for treating headache after a lumbar puncture
- Drugs other than those used for epilepsy for treating trigeminal neuralgia
- Drugs that prevent oral bleeding in people using oral anticoagulants undergoing minor oral surgery or dental extractions
- Drugs to break down blood clots for people with sudden onset peripheral arterial occlusion
- Drugs to dissolve pulmonary embolism (blood clot in the lungs)
- Drugs to help reduce anxiety in people nearing the end of life due to illness
- Drugs to relieve pain for children with acute middle ear infection
- Drugs to treat acute respiratory distress syndrome in adults
- Drugs used as add-on therapy to heart procedure following heart attack
- Duration of treatment for asymptomatic bacteriuria during pregnancy
- Early or delayed surgical removal of the appendix: which works better to treat an appendiceal mass (lump on the appendix)?
- Early palliative care for adults with advanced cancer
- Early skin-to-skin contact for mothers and their healthy newborn infants
- Early treatment with blood-thinning drugs for people who have had a stroke
- Early use of inhaled corticosteroids in the emergency department treatment of acute asthma
- Early versus delayed initiation of continuous positive airway pressure (CPAP) for respiratory distress in preterm infants
- Early versus delayed mobilisation to prevent further bleeding after spontaneous bleeding on the surface of the brain
- Echinacea for preventing and treating the common cold
- Educational games to improve health care professional practice and care for patients
- Effect of applying cricoid pressure during rapid sequence induction of general anaesthesia
- Effects of antihistamines on eczema
- Effects of higher versus lower levels of pressure in the lungs at the end of each breath during mechanical ventilation in patients with acute respiratory distress syndrome (ARDS)
- Effects of perioperative alcohol cessation interventions on postoperative complications following surgery
- Elective (regular) versus symptomatic intravenous antibiotic therapy for cystic fibrosis
- Electric fans for reducing the health effects of heatwaves
- Elevation of the head during intensive care management in people with severe traumatic brain injury
- Embolisation therapy for pulmonary arteriovenous malformations
- Endothelin receptor antagonists for subarachnoid hemorrhage
- Endovascular therapy versus conventional medical treatment for symptomatic intracranial artery stenosis
- Endovascular treatment for ruptured abdominal aortic aneurysm
- Etomidate for sedating critically ill people during emergency endotracheal intubation
- Exercise for Neck Pain
- External counterpulsation for acute ischaemic stroke
- Extracorporeal (external to the body) membrane oxygenation (ECMO) for critically ill adults
- Factors that influence whether healthcare workers follow infection prevention and control guidelines for respiratory infectious diseases
- Family presence during resuscitation
- Fibrinogen depleting agents may help to remove blood clots in acute ischaemic stroke
- First aid glucose administration routes for symptomatic hypoglycaemia
- Fixation devices secured across the fracture that are placed either directly or externally for treating hip fractures located outside the hip joint
- Fixed daily dose of a low molecular weight heparin compared with an adjusted dose of unfractionated heparin for treating blood clots in the deep veins
- Fludrocortisone for the treatment of orthostatic hypotension
- Fluid removal therapy in acute heart failure
- Fluids and diuretics for treating acute ureteric colic
- Fluids for hydration in children
- Fluids for people with acute bacterial meningitis
- Flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy
- Fluvoxamine for treating COVID-19
- Food-based oral rehydration solution for acute diarrhoea
- Full publication of results initially presented in abstracts
- Gabapentin for chronic neuropathic pain in adults
- Gamma aminobutyric acid (GABA) receptor agonists for acute stroke
- Garlic for the common cold
- Giving glutamine supplements to critically ill adults
- Glucocorticoids for acute viral bronchiolitis in infants and young children under two years of age
- Glucocorticoids for croup in children
- Glucocorticoids for the treatment of anaphylaxis
- Glucocorticosteroids for people with alcoholic hepatitis
- Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke
- H1-antihistamines for chronic spontaneous urticaria
- Haemodilution for acute ischaemic stroke
- Haloperidol as a means of calming people who are aggressive or agitated due to psychosis
- Haloperidol dose for the acute phase of schizophrenia
- Haloperidol for the treatment of nausea and vomiting in palliative care patients
- Harms and benefits of dissolving blood clots in deep blood vessels in the arms
- Health workers' perceptions and experiences of using mHealth technologies to deliver primary healthcare services: a qualitative evidence synthesis
- Heated, humidified air for the common cold
- Helicopter emergency medical services for adults with major trauma
- Heliox inhalation therapy for bronchiolitis in infants
- Helium-oxygen (heliox) treatment for children with croup
- Helminth therapy (worms) for allergic rhinitis
- High pressure (hyperbaric) oxygen therapy for Bell's palsy
- High-flow nasal cannula (tube) oxygen therapy for infants with bronchiolitis
- High-flow nasal cannulae for breathing support in adult intensive care patients
- High-frequency oscillation for the treatment of acute respiratory distress syndrome (ARDS)
- Higher or lower levels of oxygen for adults admitted to the intensive care unit
- Hip replacement surgery in adults
- Histamine-blocking drugs for hives
- Holding chambers (spacers) versus nebulisers for delivery of beta-agonist relievers in the treatment of an asthma attack
- Home versus in-patient treatment for deep vein blood clots
- Home-based end-of-life care
- Homeopathic Oscillococcinum® for preventing and treating influenza and influenza-like illness
- Honey as a topical treatment for acute and chronic wounds
- Honey for acute cough in children
- Hormone treatment may be ineffective in treating people with viral myocarditis
- How accurate are nucleic and antigen detection tests in diagnosing leptospirosis?
- How accurate are rapid antigen tests for diagnosing COVID-19?
- How accurate are routine laboratory tests for diagnosis of COVID-19?
- How accurate are symptoms and medical examination to diagnose COVID-19?
- How accurate is bedside ultrasound for the diagnosis of injuries to the abdomen or chest in patients with blunt injuries?
- How accurate is chest imaging for diagnosing COVID-19?
- How accurate is chest ultrasonography compared to supine chest radiography for diagnosis of traumatic pneumothorax in the emergency department?
- How accurate is computed tomography for the diagnosis of acute appendicitis in adults?
- How can caregivers manage pain in infants and young children undergoing painful procedures?
- How can communication about the end of life and care in the last 12 months of life be improved?
- How effective are medicines used to treat attacks of vestibular migraine?
- How effective are military and frontline emergency service personnel pre-deployment resilience building programmes?
- How effective is aripiprazole for calming people who are aggressive or agitated due to psychosis?
- How effective is screening for COVID-19?
- How often should dressings on central venous access devices (CVADs) be changed to reduce catheter-related infection?
- How similar are estimates of treatment effectiveness derived from randomised controlled trials and observational studies?
- Human recombinant activated protein C for severe sepsis and septic shock in adult and paediatric patients
- Hydrocolloid dressings to promote foot ulcer healing in people with diabetes when compared with other dressing types
- Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function
- Hydroxyurea (also known as hydroxycarbamide) for people with sickle cell disease
- Hyperbaric oxygen as an additional treatment for malignant otitis externa
- Hyperbaric oxygen for sudden hearing loss and tinnitus (ringing in the ears) of unknown cause
- Hyperbaric oxygen therapy for acute surgical and traumatic wounds
- Hyperbaric oxygen therapy for treating people with acute ischaemic stroke
- Hypothermia (body temperature cooling) for people with an injury to the brain
- Ibuprofen with or without an antiemetic for acute migraine headaches in adults
- Image-guided versus blind glucocorticoid injection for shoulder pain
- Immediate antiepileptic drug treatment, versus placebo, deferred, or no treatment for first unprovoked seizure
- Immediate closure or delayed closure for treating traumatic wounds in the first 24 hours following injury
- Immunity in vulnerable groups after COVID-19 vaccination
- Immunoglobulin treatment for Kawasaki disease
- Improving how physicians working in hospital settings prescribe antibiotics
- In people with asthma are single inhalers that contain both formoterol and budesonide better than current best practice?
- In stable COPD, should inhaled corticosteroids be used with combination long-acting beta2-agonist/long-acting muscarinic antagonist inhalers?
- Increased water intake for preventing urinary stones
- Increasing the dose of inhaled steroids or continuing the usual dose to treat asthma attacks in adults and children
- Industry sponsorship and research outcome
- Influenza vaccine for preventing acute otitis media (middle ear infection)
- Inhaled analgesia for relieving pain during labour
- Inhaled corticosteroids compared with placebo for stable chronic obstructive pulmonary disease (COPD)
- Inhaled corticosteroids for acute asthma following emergency department discharge
- Inhaled corticosteroids for subacute cough in children
- Inhaled drugs for opening up the airways in cases of acute chest syndrome in people with sickle cell disease
- Inhaled nitric oxide for treating pain crises in people with sickle cell disease
- Inotropic and vasodilator strategies in people with cardiogenic shock or low cardiac output
- Interleukin-1 inhibitors for acute gout
- Intervention to prevent delirium for critically ill patients in the intensive care unit (ICU)
- Interventions for acute severe asthma attacks in children: an overview of Cochrane Reviews
- Interventions for an acute internal hordeolum
- Interventions for managing asthma in pregnancy
- Interventions for nausea and vomiting in early pregnancy
- Interventions for paracetamol (acetaminophen) overdose
- Interventions for preventing and reducing the use of physical restraints of older people in hospital
- Interventions for the management of fluid around the lungs (pleural fluid) caused by cancer
- Interventions for the treatment of persistent smell disorders (olfactory dysfunction) after COVID-19 infection
- Interventions for treating acute elbow dislocations in adults
- Interventions for treating adults with an isolated fracture of the ulnar shaft
- Interventions for treating phosphorus burns
- Interventions for treating severe nausea and vomiting during pregnancy (hyperemesis gravidarum)
- Interventions for treating traumatised permanent front teeth: luxated (dislodged) front teeth
- Interventions to increase the use of measures to prevent the development of blood clots in hospitalized medical and surgical patients
- Interventions to prevent delirium in hospitalised patients, not including those on intensive care units
- Interventions to promote informed consent for patients undergoing surgical and other invasive healthcare procedures
- Intra-aortic balloon counterpulsation in patients with acute myocardial infarction and cardiogenic shock
- Intramedullary nails for extracapsular hip fractures in adults
- Intramuscular versus oral corticosteroids for acute asthma
- Intranasal corticosteroids for non-allergic rhinitis
- Intranasal fentanyl for the treatment of children in acute pain
- Intravenous beta2-agonists and intravenous aminophylline for acute asthma
- Intravenous fluids compared to nasogastric or orogastric tube hydration for children hospitalised with bronchiolitis
- Intravenous fluids for preventing prolonged labour in women giving birth to their first baby
- Intravenous immunoglobulin for Guillain-Barré syndrome
- Intravenous immunoglobulin for myasthenia gravis
- Intravenous immunoglobulins for treating patients with severe sepsis and septic shock
- Intravenous N-acetylcysteine compared to placebo for treatment of systemic inflammatory response syndrome and sepsis in seriously ill adults
- Intravenous naftidrofuryl for treating critical limb ischaemia
- Intubation methods for obese patients requiring general anaesthesia
- Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus?
- Is colchicine an effective treatment for people with COVID-19?
- Is home or hospital treatment better for people with blood clots in the lungs?
- Is inhaled magnesium sulfate a safe and effective treatment for people with asthma attacks?
- Is it safe to use lower blood counts (haemoglobin levels) as a trigger for blood transfusion in order to give fewer blood transfusions?
- Is it safer to deliver a baby immediately or wait if the mother has high blood pressure after 34 weeks of pregnancy that is not persistently severe?
- Is magnesium sulfate effective for chronic obstructive pulmonary disease (COPD) flare-ups?
- Is plasma from the blood of people who have recovered from COVID-19 an effective treatment for other people with COVID-19?
- Is sodium bicarbonate therapy helpful for people with acute kidney problems?
- Is surgery or observation better for people who have a severe blunt injury to the liver?
- Is taking inhaled corticosteroids only when asthma symptoms get worse as safe and effective as taking inhaled corticosteroids every day?
- Is the combination of nirmatrelvir plus ritonavir effective for treating or preventing COVID-19?
- Is there a best way to remove dead tissue from surgical wounds?
- Is treatment with corticosteroids beneficial and safe for people with pneumonia?
- Is ultrasound guidance a good option for peripheral intravenous cannulation in adults?
- Is vitamin D an effective and safe addition to antibiotics for treating children with acute pneumonia?
- Is vitamin D an effective and safe treatment for COVID-19?
- Ivermectin and permethrin for treating scabies
- Ivermectin for preventing and treating COVID-19
- Jolt accentuation of headache as a test for acute meningitis in emergency settings
- Ketogenic diets for drug-resistant epilepsy
- Lamotrigine add-on therapy for drug-resistant focal epilepsy
- Lamotrigine as add-on therapy for drug-resistant generalised tonic-clonic seizures
- Laryngeal mask airway versus bag-mask ventilation or endotracheal intubation for neonatal resuscitation
- Lateral positioning for critically ill adult patients
- Length of treatment with vitamin K antagonists and prevention of recurrence in patients with venous thromboembolism
- Leukotriene inhibitors for bronchiolitis in infants and young children
- Levels of interleukin-6 in identifying severely ill adult patients with sepsis
- Lidocaine for pain relief in people with burns
- Lidocaine for reducing propofol-induced pain on anaesthesia in adults
- Local anaesthesia (numbing medicine) that is directly applied to the skin can provide pain control for repair of skin lacerations
- Local and regional anaesthesia at the time of surgery to prevent longer-term persistent pain after surgery
- Local steroid injection for carpal tunnel syndrome
- Long-acting beta2-agonists for people with COPD
- Long-term blood transfusions to prevent a stroke in people with sickle cell disease
- Loop diuretics cause modest blood pressure lowering
- Loop diuretics for patients receiving blood transfusions
- Low blood oxygen levels versus normal blood oxygen levels in ventilated severely ill people
- Low molecular weight heparin for prevention of venous thromboembolism in adults with lower-limb immobilization in an outpatient setting
- Low-molecular-weight heparins for pain caused by obstruction of blood vessels in people with sickle cell disease
- Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth
- Magnesium for the prevention or treatment of alcohol withdrawal syndrome in adults
- Magnesium for treating sickle cell disease
- Magnetic resonance imaging (MRI) for diagnosis of acute appendicitis
- Mailuoning (a type of traditional Chinese medicine) for improving outcome in people with acute ischaemic stroke
- Management of intussusception in children
- Managing acute lower abdominal pain in women of childbearing age
- Manipulation and mobilisation for neck disorders
- Mechanical and surgical interventions for treating women with severe bleeding after childbirth
- Mechanical chest compression machines for cardiac arrest
- Mechanical heart pumps to aid a heart that fails suddenly
- Medical and surgical treatment for ocular myasthenia
- Medical therapies for treating heavy menstrual bleeding in women with bleeding disorders
- Medical treatment for people with acute pancreatitis (sudden inflammation of the pancreas)
- Medical treatment for traumatic hyphema
- Medically assisted hydration to assist palliative care patients
- Medication for posttraumatic stress disorder
- Medication for treating anxiety disorders in people with alcohol use problems
- Medications for reducing contractions during labour for excessively strong/frequent contractions or where the unborn baby is thought to be distressed
- Medicines for preventing post-traumatic stress disorder (PTSD)
- Medicines in the treatment of emergency department nausea and vomiting
- Medicines to treat delirium in critically ill adult patients
- Mefloquine for preventing malaria in pregnant women
- Melatonin to improve sleep in the intensive care unit
- Methods for securing endotracheal tubes in newborn infants
- Methods of emergency contraception
- Metoclopramide for accurate placement of naso-enteral feeding tube
- Midazolam for sedation before procedures
- Mindfulness for improving mental well-being in medical students and junior doctors
- Minimally invasive treatments to dissolve blood clots in the lungs (acute pulmonary embolism)
- Mobile phone messaging for communicating results of medical investigations
- Modifications of the Epley manoeuvre for benign paroxysmal positional vertigo (BPPV)
- Morphine for neuropathic pain in adults
- Motivational interviewing (MI) for preventing alcohol misuse in young adults is not effective enough
- Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease
- Multiple session early psychological interventions for prevention of post-traumatic stress disorder
- Muscle energy technique (MET) for non-specific low-back pain
- N-acetylcysteine for acute liver failure not caused by paracetamol overdose
- Naproxen for acute migraine in adults
- Nasal high flow therapy for breathing support in preterm babies
- Nasal saline irrigation for acute upper airway infection symptoms
- Natriuretic peptide-guided treatment for preventing death and cardiovascular events among patients with risk factors for heart disease
- Nebulized epinephrine for croup in children
- Needle aspiration compared to incision and drainage for the treatment of peritonsillar abscess (quinsy)
- Needle characteristics that reduce the occurrence of post-dural puncture headache (PDPH)
- Nerve blocks for initial pain management of thigh bone fractures in children
- Neuraminidase inhibitors for preventing and treating influenza in children
- New treatments versus established treatments in randomized trials
- Newborn resuscitation training programmes for improving the health and survival of newborns
- Nitrates for acute heart failure syndromes
- Non-drug approaches for preventing delirium in adults receiving care in hospital outside of intensive care and high dependency units
- Non-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbations of asthma
- Non-invasive ventilation for people with respiratory failure due to exacerbation of chronic obstructive pulmonary disease (COPD)
- Non-opioid drugs for managing pain in labour
- Non-pharmacological interventions for preventing secondary vascular events after stroke or transient attack
- Non-steroid anti-inflammatory drugs for biliary colic
- Non-steroidal anti-inflammatory drugs (NSAIDs) for acute gout
- Non-steroidal anti-inflammatory drugs (NSAIDs) for treating tennis elbow pain in adults
- Non-steroidal anti-inflammatory drugs for low back pain with sciatica
- Non-steroidal anti-inflammatory drugs for the common cold
- Non-surgical interventions for treating a broken collarbone in adolescents and adults
- Non-surgical management after non-surgical repositioning of traumatic anterior dislocation of the shoulder
- Nonsteroidal anti-inflammatory drugs for dysmenorrhoea
- Nonsteroidal anti-inflammatory drugs for management of pain in women with endometriosis
- Normal pressure oxygen therapy and hyperbaric oxygen therapy for migraine and cluster headaches
- Observation alone versus drain tube or needle insertion (interventional) for primary spontaneous pneumothorax in adults without previous lung disease.
- Once versus twice daily injections of low molecular weight heparin for the initial treatment of blood clots in the veins
- Opioids for abdominal pain in acute pancreatitis
- Opioids for agitation in dementia
- Opioids for managing pain in babies exposed to painful procedures
- Optimization of fluid levels in people suffering hip fractures
- Oral antibiotics for treating febrile neutropenia in cancer patients at low risk for complications
- Oral antihistamine-decongestant-analgesic combinations for the common cold
- Oral antiplatelet therapy for acute ischaemic stroke
- Oral aspirin for treatment of acute episodic tension-type headache in adults
- Oral corticosteroid treatment started by patients or parents during a severe asthma attack
- Oral ibuprofen for acute treatment of episodic tension-type headache in adults
- Oral ketoprofen for treatment of acute episodic tension-type headache in adults
- Oral non-steroidal anti-inflammatory drugs compared with other oral pain killers for sprains, strains and bruises
- Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for neuropathic pain in adults
- Oral painkillers available without prescription for acute pain
- Oral paracetamol for treatment of acute episodic tension-type headache in adults
- Oral zinc supplementation for treating diarrhoea in children
- Organised inpatient (stroke unit) care
- Osmotic therapies added to antibiotics for acute bacterial meningitis
- Outpatient treatment for cancer patient with low-risk febrile neutropaenic event is effective.
- Over-the-counter medications to help reduce cough for children and adults on antibiotics for acute pneumonia
- Oxygen therapy as part of the treatment for respiratory infections in children
- Oxygen therapy in the pre-hospital setting for sudden worsening of chronic obstructive pulmonary disease
- Oxytocin for preventing postpartum haemorrhage in non-facility birth settings
- Oxytocin injected into a vein or muscle for reducing blood loss after vaginal birth
- Oxytocin receptor antagonists for inhibiting preterm labour
- Pain in patients with inflammatory arthritis and gastrointestinal or liver problems
- Paracetamol (acetaminophen) alone, or in combination with codeine or dihydrocodeine, for neuropathic pain in adults
- Paracetamol (acetaminophen) for prevention or treatment of pain in newborns
- Paracetamol (acetaminophen) with or without an antiemetic for acute migraine in adults
- Paracetamol for low back pain
- Paracetamol for relief of perineal pain after birth
- Paracetamol for treating people with hip or knee osteoarthritis
- Partial agonists for the treatment of high blood pressure.
- Partial liquid ventilation for mechanical ventilation of severely ill children with acute lung injury and acute respiratory distress syndrome
- Partial removal of skull (decompressive craniectomy) to lower treatment-resistant high pressure in the skull and brain after traumatic brain injury
- Patch angioplasty versus primary closure for carotid endarterectomy
- Patient education for neck pain
- Patient-initiated appointments for people with chronic conditions managed in hospital outpatient settings
- Pedicle screw fixation methods for traumatic fractures of the thoracic and lumbar spine
- Pelargonium sidoides (Umckaloabo), a herbal remedy, for treating acute respiratory tract infections
- Pentasaccharides for the treatment of deep vein thrombosis
- Pharmacomechanical thrombectomy for iliofemoral deep vein thrombosis
- Phenobarbitone versus phenytoin monotherapy (single-drug treatment) for epilepsy
- Phlebotonics for haemorrhoids
- Physician use of red flags to screen for cancer in patients with new back pain
- Physician use of red flags to screen for fractured vertebrae for patients with new back pain
- Piracetam for acute ischaemic stroke
- Piracetam for reducing the incidence of painful sickle cell disease crises
- Plasma exchange for chronic inflammatory demyelinating polyradiculoneuropathy
- Plasma exchange for Guillain-Barré syndrome
- Plasma transfusion strategies for critically ill patients
- Plasma transfusions prior to insertion of lumbar puncture needles for people with abnormal coagulation
- Platelet glycoprotein IIb/IIIa blockers during percutaneous coronary intervention and as the initial treatment of acute coronary syndromes
- Platelet transfusion before surgery for people with low platelet counts
- Platelet transfusions are used to prevent bleeding in patients with low platelet counts due to treatment-induced bone marrow failure
- Platelet transfusions are used to prevent bleeding in people with low platelet counts due to treatment-induced bone marrow failure
- Platelet transfusions to treat bleeding compared with platelet transfusions to prevent bleeding in people with blood cancers receiving intensive treatment
- Platelet transfusions treated to reduce transfusion-transmitted infections for the prevention of bleeding in people with low platelet counts
- Platelet-rich therapies for musculoskeletal soft tissue injuries
- Positioning for hospitalised infants and children with acute respiratory distress
- Positive airway pressure for heart failure associated with central sleep apnoea
- Positive pressure therapy for Ménière's disease or syndrome
- Present-centered therapy (PCT) for post-traumatic stress disorder (PTSD) in adults
- Primary care professionals providing non-urgent care in hospital emergency departments
- Primary closure (immediate stitches) versus delayed closure (delayed stitches) or no closure (no stitches) for traumatic wounds due to mammalian bite
- Printed educational materials for healthcare professional practice and patient health
- Probiotics for preventing ventilator-associated pneumonia
- Probiotics for the management of functional abdominal pain disorders in children
- Procalcitonin evaluation for reducing mortality in adults with sepsis
- Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children
- Progesterone for traumatic brain injury
- Programmes, policies and work practices that reduce aggression by patients towards healthcare workers
- Prone (face-down) position for mechanical ventilation of adults with acute respiratory failure
- Prophylactic antibiotics for people with COPD
- Prophylactic blood thinners for the prevention of death and venous thromboembolism in COVID-19 outpatients
- Prophylactic drug management for febrile seizures in children
- Prophylactic lidocaine for myocardial infarction
- Propofol versus thiopental sodium for the treatment of refractory status epilepticus (RSE)
- Protective clothes and equipment for healthcare workers to prevent them catching coronavirus and other highly infectious diseases
- Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non-bleeding patients
- Proton pump inhibitor treatment started before endoscopy in upper gastrointestinal bleeding
- Psychological strategies to reduce pain and distress for children and adolescents getting needles
- Psychological therapies for the treatment of post-traumatic stress disorder in children and adolescents
- Psychosocial therapy for recurrent abdominal pain in childhood
- Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria
- Racecadotril to treat children under five years of age with acute diarrhoea
- Radial artery versus femoral artery approach for performing coronary catheter procedures in people with coronary artery disease
- Rapid diagnostic tests for plague
- Rapid diagnostic tests for visceral leishmaniasis
- Rapid diagnostic tests versus clinical diagnosis for managing fever in settings where malaria is common
- Rapid tests for diagnosing malaria caused by in people living in areas where malaria is very common
- Rapid tests for diagnosing malaria caused by Plasmodium vivax or other less common parasites
- Rapid viral testing for children in the Emergency Department with fever and respiratory symptoms
- Recanalisation therapies for wake-up stroke
- Recombinant (non-human) factor VIIa clotting factor concentrates versus plasma concentrates for acute bleeds in people with haemophilia and inhibitors
- Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia
- Recruitment manoeuvres as a ventilation strategy for adults with acute respiratory failure due to lung injury
- Regular or selected use of computed tomography (CT) scanning to reduce deaths in people who have a high-energy blunt-traumatic injury
- Regular treatment with formoterol and inhaled steroids for chronic asthma: serious adverse events
- Regulatory information on trials of oseltamivir (Tamiflu) and zanamivir (Relenza) for influenza in adults and children
- Rehabilitation as part of treatment for adults with a broken wrist
- Rehabilitation following an injury to the hamstring in adults
- Remdesivir to treat people with COVID-19
- Renin angiotensin system inhibitors versus other types of medicine for hypertension
- Repeated use of hormonal drugs right before or after sex to prevent pregnancy
- Replacing a peripheral venous catheter when clinically indicated versus routine replacement
- Replacing fluids to treat acute episodes of pain in people with sickle cell disease
- Risperidone as a means of calming people who are aggressive or agitated due to psychosis
- Role of ketamine for management of acute severe asthma in children
- Routine invasive versus conservative strategies for unstable angina and non-ST elevation myocardial infarction in the stent era
- Routine use of oxygen in people who have had a heart attack
- Routine vaginal examinations in labour
- Scanning imaging techniques for the exclusion of pulmonary embolism during pregnancy
- Screening people over 65 years of age for atrial fibrillation increases the rate of detection
- Screening with urinary dipsticks for reducing morbidity and mortality
- Screening women for intimate partner violence in healthcare settings
- Search strategies to identify diagnostic accuracy studies in MEDLINE and EMBASE
- Sedation medication for relieving symptoms at the end of life
- Sedation of children undergoing dental treatment
- Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) for preventing tension-type headache
- Selective versus routine use of episiotomy for vaginal birth
- Short-course versus long-course antibiotic treatment for hospital-acquired pneumonia in adult intensive care patients
- Short-term treatment with medications for heartburn symptoms
- Should patients experiencing sudden cardiac death be cooled to lower their body temperature prior to or after admission to hospital?
- Should prophylactic antibiotics be used in patients with penetrating abdominal trauma?
- Simple aspiration versus intercostal tube drainage for primary spontaneous pneumothorax in adults
- Simulation-based obstetric team training to improve the overall outcome of obstetric health care
- Skin antisepsis for reducing central venous catheter-related infections
- Skin-to-skin care with newborns cuts down procedural pain
- SmartCare™ versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults
- Smectite for treating children with acute diarrhoea
- Snake antivenoms for treating people who have been bitten by a snake, and have developed abnormal blood clotting
- Somatostatin analogues for acute bleeding oesophageal varices
- Specialist teams for neonatal transport to neonatal intensive care units for prevention of morbidity and mortality
- Spectrum of the initial antibiotic treatment for cancer patients with fever and low leucocytes counts
- Splints and other non-surgical methods for treating common injuries of the middle joints of the fingers
- Steroidal anti-inflammatory medication given by mouth or injection for acute sinusitis
- Steroids for acute sinusitis in adults and children
- Steroids for acute spinal cord injury
- Steroids for short-term symptom control in infectious mononucleosis (glandular fever)
- Steroids for the common cold
- Steroids for the treatment of influenza
- Steroids for the treatment of sudden hearing loss with unknown cause
- Steroids in the treatment of traumatic optic neuropathy
- Stopping antibiotic therapy early versus continuing until normal neutrophil count in people with cancer with fever and low neutrophil counts
- Subcutaneous rapid-acting insulin analogues for diabetic ketoacidosis
- Subcutaneous unfractionated heparin for the initial treatment of venous thromboembolism
- Sublingual immunotherapy for asthma
- Substituting or adding fluoroquinolones to established first-line antituberculous drug regimens gives no additional benefit or risks
- Sucrose for analgesia (pain relief) in newborn infants undergoing heel lance
- Sucrose for analgesia (pain relief) in newborn infants undergoing painful procedures
- Sumatriptan (oral route of administration) for acute migraine attacks in adults
- Sumatriptan (subcutaneous route of administration) for acute migraine attacks in adults
- Sumatriptan plus naproxen for acute migraine attacks in adults
- Surgery for small abdominal aortic aneurysms that do not cause symptoms
- Surgery for unstable trauma patients
- Surgery or non-surgical treatments: which works better to treat people who have a dislocated knee cap?
- Surgery versus observation for people with abdominal injury
- Surgery versus thrombolysis for the initial management of acute limb ischaemia
- Surgical approaches for dislocations of the neck bones
- Surgical decompression for cerebral oedema in acute ischaemic stroke
- Surgical interventions for treating fractures of the olecranon (an elbow bone) in adults
- Surgical interventions for treating radial head fractures in adults
- Surgical versus conservative for treatment for acromioclavicular dislocations of the shoulder in adults
- Surgical versus conservative interventions for treating anterior cruciate ligament injuries
- Surgical versus conservative interventions for treating broken collarbones in adolescents and adults
- Surgical versus conservative treatment for ankle fractures in adults
- Surgical versus non-surgical interventions for treating humeral shaft fractures in adults
- Surgical versus non-surgical treatment for thoracolumbar burst fractures without neurological deficit
- Swallowing therapy for difficulties with swallowing in stroke survivors who have had a recent stroke
- Sweet taste to ease injection needle pain in children aged one to 16 years
- Synchronised mechanical ventilation for respiratory support in newborn infants
- Systematic review of randomised controlled trials about the efficacy and safety of colchicine in people with pericarditis
- Systemic corticosteroids for improving symptoms in children with acute middle ear infection
- Systemic corticosteroids for radicular and non-radicular low back pain
- TEG and ROTEM for diagnosing trauma‑induced coagulopathy (disorder of the clotting system) in adult trauma patients with bleeding
- Terbutaline pump maintenance therapy after threatened preterm labour for reducing adverse neonatal outcomes
- Testing blood procalcitonin levels to decide when to start and stop antibiotics in adults with acute respiratory tract infections
- The accuracy of rapid diagnostic tests for detecting typhoid and paratyphoid (enteric) fever
- The aspiration of pneumothorax in the newborn with a small needle compared to a larger tube placed through the intercostal space
- The effect of automatically generated reminders delivered to providers on paper on quality of care and patient outcomes
- The effect of removing or reducing lactose from milk in young children with acute diarrhoea
- The effect of short duration versus standard duration antibiotic therapy for streptococcal throat infection in children
- The effectiveness of blood testing in the management of pyelonephritis in pregnancy for improving outcomes
- The effectiveness of oxygen for adult patients with pneumonia
- The effectiveness of the Valsalva Manoeuvre for stopping an abnormal heart rhythm
- The effects of interactive training of healthcare providers on the management of life-threatening emergencies in hospital
- The effects of using email to send test results to patients
- The effects of water compared with other solutions for wound cleansing
- The Epley manoeuvre for benign paroxysmal positional vertigo (BPPV)
- The Lund concept in the treatment of brain injuries
- The optimal warfarin dose for patients beginning therapy
- The risk of heart attack and stroke in women using birth control pills
- The use of benzodiazepines to treat adults with delirium, excluding patients being cared for in intensive care units (ICU)
- The use of computed tomography angiography (CTA) to confirm the clinical diagnosis of brain death
- The use of lower blood pressure targets for people with hypertension
- The use of respiratory support without endotracheal tube (i.e. non-invasive) in babies to manage rapid breathing (transient tachypnea of the newborn)
- The use of telephone for the delivery of HIV testing results
- Therapeutic hypothermia as a neuroprotective therapy after cardiopulmonary arrest in children
- Thiamine for prevention and treatment of Wernicke-Korsakoff syndrome in people who abuse alcohol
- Thiazides best first choice for hypertension
- Thrombolysis for treatment of acute deep vein thrombosis
- Thrombophilia testing for the prevention of recurrent venous thromboembolism
- Timing of initiation of kidney replacement therapy (dialysis) for acute kidney injury
- Tiotropium for managing COPD
- Tiotropium versus ipratropium bromide in the management of COPD
- Tissue adhesives for closure of surgical skin incisions
- Tocolytics for preterm premature rupture of membranes
- Topical antibiotics to help reduce death and respiratory infections in people in intensive care receiving mechanical ventilation
- Topical antiseptics compared with antibiotics for people with chronic suppurative otitis media
- Topical non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of pain in traumatic corneal abrasions
- Topical non-steroidal anti-inflammatory drugs for acute musculoskeletal pain in adults
- Topical treatment for facial burns
- Topical treatment with a blood-clot promoting drug to reduce bleeding
- Training healthcare providers to respond to intimate partner violence against women
- Training interventions for improving telephone consultation skills in clinicians
- Tranexamic acid to help treat nosebleeds (epistaxis)
- Tranexamic acid, an agent that promotes blood clotting, for serious or uncontrolled upper gastrointestinal bleeding
- Transcranial colour Doppler (TCD) and transcranial colour-coded duplex (TCCD), in patients with acute ischaemic stroke for detecting intracranial vessel occlusion or stenosis
- Transcutaneous Electrical Nerve Stimulation (TENS) to treat acute pain in adults
- Treatment for bleeding from enlarged veins in the oesophagus (food pipe) in people with advanced scarring of the liver
- Treatment for excessive bleeding after childbirth
- Treatment for superficial infusion thrombophlebitis of the upper extremity
- Treatment for superficial thrombophlebitis of the leg
- Treatment of below-the-knee deep vein thrombosis
- Treatment of epilepsy for people with Alzheimer's disease
- Treatment of hepatorenal syndrome
- Treatment of severe blunt pancreatic lesions in children
- Treatment of the cough in whooping cough
- Treatments for acute bleeds in people with acquired hemophilia A
- Treatments for acute central retinal artery occlusion (blockage of the blood supply to the retina of the eye)
- Treatments for breaks in the lower part of the thigh bone in adults
- Treatments for broken ankles in children
- Treatments for broken kneecaps in adults
- Treatments for delusional disorder
- Treatments for depression in individuals with coronary artery disease
- Treatments for fingertip entrapment injuries in children
- Treatments for high altitude (mountain) illness
- Treatments for long-lasting and painful erection of the penis in boys and men with sickle cell disease
- Treatments for preventing and treating low-back and pelvic pain during pregnancy
- Treatments through the artery versus clot-dissolving drugs for the early treatment of stroke
- Treatments to help blood clotting to improve the recovery of adults with stroke due to bleeding in the brain
- Treatments to prevent Sudden Unexpected Death in Epilepsy (SUDEP)
- Triptans for acute cluster headache
- Tube feeding in patients with acute pancreatitis
- Type of electrical shock to restart the heart in a non-hospitalised person whose heart stops beating
- Types of urethral catheters for management of short-term voiding problems in hospitalised adults
- Ultrasound (high-frequency sound waves) plus a clot-busting drug for breaking down a blood clot blocking a blood vessel in the brain
- Ultrasound and liver function tests for the diagnosis of common bile duct stones
- Ultrasound and shockwave treatment for recently broken bones in adults
- Ultrasound guidance for injecting local anaesthetics in children to block pain transmission
- Ultrasound guidance versus anatomical landmarks for internal jugular vein catheterization
- Ultrasound guidance versus anatomical landmarks for subclavian or femoral vein catheterization
- Ultrasound to guide arterial (other than femoral) punctures and cannulation in adults
- Ultrasound use for insertion of arterial catheters in children
- Urinary alkalisation for uncomplicated urinary tract infections
- Urinary catheter policies for long-term bladder drainage
- Use of adrenaline with lidocaine for surgery on fingers and toes
- Use of capnography in emergency department patients being sedated for procedures
- Use of corticosteroids for treatment of the newborn with bacterial meningitis
- Use of fibrinogen concentrate in patients with bleeding
- Use of inhaled nitric oxide in patients with acute respiratory failure with low blood oxygen does not improve survival
- Use of multiple versus fewer antiplatelet drugs for preventing early recurrence after stroke or transient ischaemic attack
- Use of noninvasive ventilation (a mask ventilator) holds promise as a method to make it easier to remove adults from conventional ventilators.
- Use of platelet transfusions prior to a lumbar puncture or epidural anaesthetic in people with a low platelet count
- Use of rapid point-of-care testing for strep throat to guide doctors prescribing antibiotics for sore throat in primary care settings
- Using corticosteroids to treat Kawasaki disease
- Using email for healthcare professionals to contact each other
- Using mobile technologies to promote communication and management of care between healthcare professionals
- Using oxygen at high pressure (in a compression chamber) for the treatment of broken bones
- Using oxygen at high pressure (in a compression chamber) for the treatment of individuals with severe soft tissue infection (necrotizing fasciitis)
- Using ultrasound to aid diagnosis of patients with a 'blunt' injury to the abdomen
- Uterine massage for preventing postpartum haemorrhage
- Vaccines for preventing flu in people with asthma
- Vaginal inserts for prevention of sexually transmitted infections
- Valacyclovir compared with acyclovir for the treatment of herpes zoster ophthalmicus in people with an otherwise normal immune system
- Valproate preparations for the treatment of agitated behaviour in people with dementia
- Vapocoolants (cold spray) for pain treatment during intravenous cannulation
- Varying the timing or the volume of intravenous fluids given to people with uncontrolled bleeding due to injury
- Vasopressors for hypotensive shock
- Vena caval filters for the prevention of pulmonary embolism
- Vestibular rehabilitation to improve dizziness, balance and mobility in patients with unilateral peripheral vestibular dysfunction
- Vitamin C for preventing and treating pneumonia
- Vitamin C for preventing and treating tetanus
- Vitamin C for preventing and treating the common cold
- Vitamin K antagonists or low-molecular-weight heparin for long term treatment of symptomatic blood clots
- Vitamin K for upper gastrointestinal bleeding in people with acute or chronic liver diseases
- Vitamins C and E for asthma and exercise-induced breathlessness
- Warfarin initiation nomograms of 5 mg and 10 mg for venous thromboembolism
- What are healthcare stakeholders’ perceptions and experiences of factors affecting the implementation of critical care telemedicine?
- What are the benefits and harms of antibiotics for acute bacterial conjunctivitis?
- What are the benefits and harms of different treatments for jellyfish stings?
- What are the benefits and harms of diuretics given as a first treatment compared to other drug classes for hypertension (high blood pressure)?
- What are the benefits and harms of nonsteroidal anti-inflammatory drugs (NSAIDs) for treating acute renal colic?
- What are the benefits and risks of atovaquone-proguanil for treating uncomplicated malaria caused by the Plasmodium falciparum parasite?
- What are the benefits and risks of different treatments for bacterial folliculitis and boils (inflammation of the skin around hairs)?
- What are the benefits and risks of erythromycin given before endoscopy for people with intestinal bleeding?
- What are the benefits and risks of giving corticosteroids to pregnant women at risk of premature birth?
- What are the benefits and risks of hypertonic saline solution via nebuliser for treating infants with acute bronchiolitis, compared to normal saline solution?
- What are the benefits and risks of medication reviews for hospitalised adults?
- What are the benefits and risks of tranexamic acid for preventing heavy bleeding after vaginal birth?
- What are the benefits and risks of treating broken heel bones with or without an operation?
- What are the benefits and risks of treating paraquat poisoning with a combination of steroids and cyclophosphamide (an anti-cancer medicine)?
- What are the benefits and risks of using virtual reality in a healthcare setting to distract children from pain?
- What are the best ways of treating adults with a fractured (broken) shoulder?
- What are the effects of antibiotics on pain and swelling caused by inflammation or infection at the root of the tooth in adults?
- What are the effects of corticosteroids on preventing postherpetic neuralgia?
- What are the effects of stopping blood pressure medications in older people?
- What are the likely benefits and harms of non-medicine and non-surgical treatments for non-specific low back pain?
- What is the best regimen of proton pump inhibitors for bleeding peptic ulcers?
- What is the diagnostic accuracy of antibody tests for the detection of infection with the COVID-19 virus?
- What is the evidence for the benefit and harms of anticoagulants for heart failure?
- What is the performance of rapid tests for the diagnosis of strep throat in children?
- What type of heart and blood vessel problems complicate COVID-19 infections, how common are they and what other medical conditions do these patients have?
- Which approaches help with recovery after a broken ankle in adults?
- Which drug is best for treating excessive bleeding after childbirth?
- Which medication is best for reducing excessive blood loss after childbirth and has the fewest unwanted effects?Updated
- Which route of short-term bladder drainage is best for adults in hospital?
- Which treatments are best for symptoms in COVID-19 patients at the end of life?
- Which types of blood-thinning drugs (anticoagulants) are best to prevent blood clots in people soon after stroke?
- Xiongshao capsule preventing restenosis after percutaneous coronary intervention in patients with coronary heart disease
- Zolmitriptan for acute migraine attacks in adults
- EAR NOSE AND THROAT - STOMATOLOGY (45)
- A spray containing ipratropium bromide administered into the nose to treat common cold symptoms
- Acetaminophen (also called paracetamol) for the common cold in adults
- Antibiotic use for severe toothache (irreversible pulpitis)
- Antibiotics for acute middle ear infection (acute otitis media) in children
- Antibiotics for adults and children with sore throats
- Antibiotics for otitis media with effusion ('glue ear') in children
- Antibiotics for sinus infection of short duration in adults
- Antibiotics to treat adults with acute laryngitis
- Antihistamines to prevent and treat motion sickness
- Antiviral drugs for sudden hearing loss (without known cause)
- Antiviral treatment for Bell's palsy
- Corticosteroids as stand-alone or add-on treatment for sore throat
- Corticosteroids for Bell's palsy
- Decongestants, antihistamines and nasal irrigation for acute sinusitis in children
- Different antibiotics for group A streptococcal pharyngitis
- Do nasal decongestants used alone relieve cold symptoms?
- Dosage intervals of amoxicillin for the treatment of acute middle ear infection
- Drugs that prevent oral bleeding in people using oral anticoagulants undergoing minor oral surgery or dental extractions
- Drugs to relieve pain for children with acute middle ear infection
- Glucocorticoids for croup in children
- Helium-oxygen (heliox) treatment for children with croup
- Hyperbaric oxygen as an additional treatment for malignant otitis externa
- Hyperbaric oxygen for sudden hearing loss and tinnitus (ringing in the ears) of unknown cause
- Influenza vaccine for preventing acute otitis media (middle ear infection)
- Interventions for treating traumatised permanent front teeth: luxated (dislodged) front teeth
- Intranasal corticosteroids for non-allergic rhinitis
- Modifications of the Epley manoeuvre for benign paroxysmal positional vertigo (BPPV)
- Nasal saline irrigation for acute upper airway infection symptoms
- Nebulized epinephrine for croup in children
- Needle aspiration compared to incision and drainage for the treatment of peritonsillar abscess (quinsy)
- Oral antihistamine-decongestant-analgesic combinations for the common cold
- Pelargonium sidoides (Umckaloabo), a herbal remedy, for treating acute respiratory tract infections
- Positive pressure therapy for Ménière's disease or syndrome
- Sedation of children undergoing dental treatment
- Steroidal anti-inflammatory medication given by mouth or injection for acute sinusitis
- Steroids for acute sinusitis in adults and children
- Steroids for the treatment of sudden hearing loss with unknown cause
- Systemic corticosteroids for improving symptoms in children with acute middle ear infection
- The Epley manoeuvre for benign paroxysmal positional vertigo (BPPV)
- Topical antiseptics compared with antibiotics for people with chronic suppurative otitis media
- Tranexamic acid to help treat nosebleeds (epistaxis)
- Use of rapid point-of-care testing for strep throat to guide doctors prescribing antibiotics for sore throat in primary care settings
- Vestibular rehabilitation to improve dizziness, balance and mobility in patients with unilateral peripheral vestibular dysfunction
- What are the effects of antibiotics on pain and swelling caused by inflammation or infection at the root of the tooth in adults?
- What is the performance of rapid tests for the diagnosis of strep throat in children?
- ANESTHESIA AND PAIN CONTROL (39)
- ANESTHESIA (12)
- A comparison of a local anaesthetic injection below the collarbone with other injection techniques for providing anaesthesia of the lower arm
- Clonazepam for neuropathic pain and fibromyalgia in adults
- Clonidine, lofexidine, and similar medications for the management of opioid withdrawal
- Comparison of propofol (an anaesthetic drug) with other drug options for sedating people undergoing painful procedures in emergency departments
- Comparison of two muscle relaxants, rocuronium and succinylcholine, to facilitate rapid sequence induction intubation
- Dexmedetomidine and clonidine for long-term sedation during mechanical ventilation in critically ill patients
- Different methods of ventilation (controlling pressure vs volume) for people with acute respiratory failure due to lung injury
- Etomidate for sedating critically ill people during emergency endotracheal intubation
- Lidocaine for reducing propofol-induced pain on anaesthesia in adults
- Midazolam for sedation before procedures
- Topical antibiotics to help reduce death and respiratory infections in people in intensive care receiving mechanical ventilation
- Ultrasound guidance for injecting local anaesthetics in children to block pain transmission
- PAIN CONTROL (27)
- Caffeine as an analgesic adjuvant for acute pain in adults
- Clonazepam for neuropathic pain and fibromyalgia in adults
- Codeine, alone and with paracetamol (acetaminophen), for cancer pain
- Do painkillers rubbed on the skin really work?
- Drug treatments for pain in children and young people with life-limiting conditions
- Drugs other than those used for epilepsy for treating trigeminal neuralgia
- Haloperidol for the treatment of nausea and vomiting in palliative care patients
- How can caregivers manage pain in infants and young children undergoing painful procedures?
- Intranasal fentanyl for the treatment of children in acute pain
- Local anaesthesia (numbing medicine) that is directly applied to the skin can provide pain control for repair of skin lacerations
- Local and regional anaesthesia at the time of surgery to prevent longer-term persistent pain after surgery
- Medically assisted hydration to assist palliative care patients
- Morphine for neuropathic pain in adults
- Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for neuropathic pain in adults
- Oral painkillers available without prescription for acute pain
- Sedation medication for relieving symptoms at the end of life
- Skin-to-skin care with newborns cuts down procedural pain
- Sucrose for analgesia (pain relief) in newborn infants undergoing heel lance
- Sucrose for analgesia (pain relief) in newborn infants undergoing painful procedures
- Sweet taste to ease injection needle pain in children aged one to 16 years
- Topical non-steroidal anti-inflammatory drugs for acute musculoskeletal pain in adults
- Transcutaneous Electrical Nerve Stimulation (TENS) to treat acute pain in adults
- Treatments for high altitude (mountain) illness
- Vapocoolants (cold spray) for pain treatment during intravenous cannulation
- What are the benefits and harms of different treatments for jellyfish stings?
- What are the benefits and risks of using virtual reality in a healthcare setting to distract children from pain?
- What are the effects of corticosteroids on preventing postherpetic neuralgia?
- ANESTHESIA (12)
- BLOOD DISORDERS AND CANCER (36)
- CANCER (8)
- Antibiotics to prevent bacterial infections due to chemotherapy in cancer patients with a low white blood cell count and no fever
- Calcitonin used to treat metastatic bone pain
- Corticosteroids for the management of cancer-related breathlessness in adults with cancer
- Early palliative care for adults with advanced cancer
- Oral antibiotics for treating febrile neutropenia in cancer patients at low risk for complications
- Outpatient treatment for cancer patient with low-risk febrile neutropaenic event is effective.
- Spectrum of the initial antibiotic treatment for cancer patients with fever and low leucocytes counts
- Stopping antibiotic therapy early versus continuing until normal neutrophil count in people with cancer with fever and low neutrophil counts
- SICKLE CELL DISEASE (14)
- Antibiotics for treating acute chest syndrome in people with sickle cell disease
- Antibiotics for treating osteomyelitis in people with sickle cell disease
- Antibiotics for treating pneumonia caught outside of hospital or care homes in people with sickle cell disease
- Blood transfusions for people with sickle cell disease before they undergo surgery
- Blood transfusions for treating acute chest syndrome in people with sickle cell disease
- Hydroxyurea (also known as hydroxycarbamide) for people with sickle cell disease
- Inhaled drugs for opening up the airways in cases of acute chest syndrome in people with sickle cell disease
- Inhaled nitric oxide for treating pain crises in people with sickle cell disease
- Long-term blood transfusions to prevent a stroke in people with sickle cell disease
- Low-molecular-weight heparins for pain caused by obstruction of blood vessels in people with sickle cell disease
- Magnesium for treating sickle cell disease
- Piracetam for reducing the incidence of painful sickle cell disease crises
- Replacing fluids to treat acute episodes of pain in people with sickle cell disease
- Treatments for long-lasting and painful erection of the penis in boys and men with sickle cell disease
- BLOOD DISORDERS-OTHER (14)
- Alternative or additional agents to platelet transfusions to prevent bleeding in people with blood cancers receiving intensive treatment
- Antibiotics to prevent bacterial infections due to chemotherapy in cancer patients with a low white blood cell count and no fever
- Antifibrinolytics (tranexamic acid and epsilon-aminocaproic acid) to prevent bleeding in people with low platelets due to bone marrow failure
- Different doses of platelet transfusion for preventing bleeding in people with low platelet counts due to treatment-induced bone marrow failure
- Is it safe to use lower blood counts (haemoglobin levels) as a trigger for blood transfusion in order to give fewer blood transfusions?
- Plasma transfusions prior to insertion of lumbar puncture needles for people with abnormal coagulation
- Platelet transfusion before surgery for people with low platelet counts
- Platelet transfusions are used to prevent bleeding in patients with low platelet counts due to treatment-induced bone marrow failure
- Platelet transfusions are used to prevent bleeding in people with low platelet counts due to treatment-induced bone marrow failure
- Platelet transfusions to treat bleeding compared with platelet transfusions to prevent bleeding in people with blood cancers receiving intensive treatment
- Prothrombin complex concentrate for reversal of vitamin K antagonist treatment in bleeding and non-bleeding patients
- Recombinant (non-human) factor VIIa clotting factor concentrates versus plasma concentrates for acute bleeds in people with haemophilia and inhibitors
- The optimal warfarin dose for patients beginning therapy
- Treatments for acute bleeds in people with acquired hemophilia A
- CANCER (8)
- EDUCATION (11)
- EDUCATION-OTHER (9)
- Do education and training programs reduce aggressive behavior toward healthcare workers?
- How can communication about the end of life and care in the last 12 months of life be improved?
- Interventions to promote informed consent for patients undergoing surgical and other invasive healthcare procedures
- Printed educational materials for healthcare professional practice and patient health
- Screening women for intimate partner violence in healthcare settings
- The effects of interactive training of healthcare providers on the management of life-threatening emergencies in hospital
- Training healthcare providers to respond to intimate partner violence against women
- Training interventions for improving telephone consultation skills in clinicians
- What are the benefits and risks of medication reviews for hospitalised adults?
- SIMULATION (2)
- EDUCATION-OTHER (9)
- EMERGENCY MEDICAL SYSTEM (EMS) MANAGEMENT - PUBLIC HEALTH - LEGAL MEDICINE (22)
- EMERGENCY MEDICAL SYSTEM MANAGEMENT (18)
- Are interventions to improve clinical incidence reporting effective?
- Audit and feedback: effects on professional practice
- Comparing walk-in clinics to physician offices and emergency rooms
- Discharge planning from hospital
- Health workers' perceptions and experiences of using mHealth technologies to deliver primary healthcare services: a qualitative evidence synthesis
- Helicopter emergency medical services for adults with major trauma
- Home-based end-of-life care
- How effective are military and frontline emergency service personnel pre-deployment resilience building programmes?
- Improving how physicians working in hospital settings prescribe antibiotics
- Mindfulness for improving mental well-being in medical students and junior doctors
- Mobile phone messaging for communicating results of medical investigations
- Primary care professionals providing non-urgent care in hospital emergency departments
- Programmes, policies and work practices that reduce aggression by patients towards healthcare workers
- The effect of automatically generated reminders delivered to providers on paper on quality of care and patient outcomes
- The effects of using email to send test results to patients
- Using email for healthcare professionals to contact each other
- Using mobile technologies to promote communication and management of care between healthcare professionals
- What are healthcare stakeholders’ perceptions and experiences of factors affecting the implementation of critical care telemedicine?
- LEGAL MEDICINE (0)
- PUBLIC HEALTH (4)
- Adult patient access to electronic health records
- Conflicts of interest and recommendations in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews
- Does cleaning hands with ash stop or reduce the spread of viral and bacterial infections compared with soap or other materials?
- Patient-initiated appointments for people with chronic conditions managed in hospital outpatient settings
- EMERGENCY MEDICAL SYSTEM MANAGEMENT (18)
- ETHICS - RESEARCH (9)
- ETHICS (0)
- RESEARCH (9)
- Audio-visual presentation of information used in the informed consent process for people considering entering clinical trials
- Bias due to selective inclusion and reporting of outcomes and analyses in systematic reviews of randomised trials of healthcare interventions
- Comparison of central adjudication of outcomes and onsite outcome assessment on treatment effect estimates
- CONsolidated Standards Of Reporting Trials (CONSORT) and the completeness of reporting of randomised controlled trials published in medical journals
- Full publication of results initially presented in abstracts
- How similar are estimates of treatment effectiveness derived from randomised controlled trials and observational studies?
- Industry sponsorship and research outcome
- New treatments versus established treatments in randomized trials
- Search strategies to identify diagnostic accuracy studies in MEDLINE and EMBASE
- ENDOCRINE AND METABOLIC (6)
- DIABETES (5)
- Alginate dressings for healing foot ulcers in people with diabetes mellitus
- Antibiotics to treat foot infections in people with diabetes
- First aid glucose administration routes for symptomatic hypoglycaemia
- Hydrocolloid dressings to promote foot ulcer healing in people with diabetes when compared with other dressing types
- Subcutaneous rapid-acting insulin analogues for diabetic ketoacidosis
- ENDOCRINE AND METABOLIC-OTHER (1)
- DIABETES (5)
- GASTROENTEROLOGY (41)
- DIGESTIVE BLEEDING (10)
- Antifibrinolytic amino acids for upper gastrointestinal bleeding in people with acute or chronic liver disease
- Band ligation versus no intervention for primary prevention of upper gastrointestinal bleeding in people with cirrhosis and oesophageal varices
- Banding ligation versus beta-blockers for primary prevention in oesophageal varices in adults
- Proton pump inhibitor treatment started before endoscopy in upper gastrointestinal bleeding
- Somatostatin analogues for acute bleeding oesophageal varices
- Tranexamic acid, an agent that promotes blood clotting, for serious or uncontrolled upper gastrointestinal bleeding
- Treatment for bleeding from enlarged veins in the oesophagus (food pipe) in people with advanced scarring of the liver
- Vitamin K for upper gastrointestinal bleeding in people with acute or chronic liver diseases
- What are the benefits and risks of erythromycin given before endoscopy for people with intestinal bleeding?
- What is the best regimen of proton pump inhibitors for bleeding peptic ulcers?
- HEPATITIS (1)
- GASTROENTEROLOGY-OTHER (30)
- Antibiotic therapy for Clostridium difficile-associated diarrhoea in adults
- Antibiotic treatment for spontaneous bacterial peritonitis in people with advanced liver disease
- Antibiotics for non-typhoidal Salmonella diarrhoea
- Antibiotics for uncomplicated diverticulitis
- Balanced crystalloid solutions versus 0.9% saline for severely dehydrated children with acute diarrhoea
- Blood and urine tests for the diagnosis of acute pancreatitis (sudden inflammation of pancreas)
- Blood tests for the diagnosis of pancreatic necrosis (pancreatic destruction due to inflammation of pancreas)
- Branched-chain amino acids improve symptoms of hepatic encephalopathy
- Cephalosporin antibiotics for the treatment of enteric fever (typhoid fever)
- Drug treatments that specifically target ammonia for adults with cirrhosis and hepatic encephalopathy
- Early or delayed surgical removal of the appendix: which works better to treat an appendiceal mass (lump on the appendix)?
- Flumazenil versus placebo or no intervention for people with cirrhosis and hepatic encephalopathy
- Food-based oral rehydration solution for acute diarrhoea
- How accurate is computed tomography for the diagnosis of acute appendicitis in adults?
- Magnetic resonance imaging (MRI) for diagnosis of acute appendicitis
- Managing acute lower abdominal pain in women of childbearing age
- Medical treatment for people with acute pancreatitis (sudden inflammation of the pancreas)
- Medicines in the treatment of emergency department nausea and vomiting
- Metoclopramide for accurate placement of naso-enteral feeding tube
- N-acetylcysteine for acute liver failure not caused by paracetamol overdose
- Non-steroid anti-inflammatory drugs for biliary colic
- Opioids for abdominal pain in acute pancreatitis
- Oral zinc supplementation for treating diarrhoea in children
- Phlebotonics for haemorrhoids
- Psychosocial therapy for recurrent abdominal pain in childhood
- Short-term treatment with medications for heartburn symptoms
- The effect of removing or reducing lactose from milk in young children with acute diarrhoea
- Treatment of hepatorenal syndrome
- Tube feeding in patients with acute pancreatitis
- Ultrasound and liver function tests for the diagnosis of common bile duct stones
- DIGESTIVE BLEEDING (10)
- GERIATRICS (0)
- HEART AND CIRCULATION (108)
- ARYTHMIA (8)
- Adenosine versus intravenous calcium channel antagonists for tachycardia in adults
- Antiarrhythmics for maintaining sinus rhythm (normal heartbeat) after reversing atrial fibrillation (correcting an irregular heartbeat)
- Benefits and harms of ablation for people with non-paroxysmal atrial fibrillation
- Comparing two types of blood-thinning drugs, factor Xa inhibitors and vitamin K antagonists, to prevent blood clots in people with atrial fibrillation
- Direct oral anticoagulants for prevention of stroke in atrial fibrillation patients with chronic kidney disease
- Direct thrombin inhibitors compared with vitamin K antagonists in people with atrial fibrillation for preventing stroke
- Screening people over 65 years of age for atrial fibrillation increases the rate of detection
- The effectiveness of the Valsalva Manoeuvre for stopping an abnormal heart rhythm
- CARDIAC ARREST (12)
- Active compression-decompression using a hand-held device for emergency heart massage
- Adrenaline and vasopressin for cardiac arrest
- Aminophylline for cardiac arrest
- Community first responders for out-of-hospital cardiac arrest in adults and children
- Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation (CPR) of non-asphyxial out-of-hospital cardiac arrest (OHCA)
- Cooling the body after resuscitation following cardiac arrest
- Family presence during resuscitation
- Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth
- Mechanical chest compression machines for cardiac arrest
- Should patients experiencing sudden cardiac death be cooled to lower their body temperature prior to or after admission to hospital?
- Therapeutic hypothermia as a neuroprotective therapy after cardiopulmonary arrest in children
- Type of electrical shock to restart the heart in a non-hospitalised person whose heart stops beating
- DEEP VEIN THROMBOSIS (18)
- Are direct oral anticoagulants (a type of 'blood thinner') better than conventional anticoagulation for treating people with a blood clot in a deep vein?
- Are inflatable sleeves and medication effective to prevent deep vein thrombosis and pulmonary embolism after surgery?
- Blood thinners for the initial treatment of blood clots in people with cancer
- Fixed daily dose of a low molecular weight heparin compared with an adjusted dose of unfractionated heparin for treating blood clots in the deep veins
- Harms and benefits of dissolving blood clots in deep blood vessels in the arms
- Home versus in-patient treatment for deep vein blood clots
- Interventions to increase the use of measures to prevent the development of blood clots in hospitalized medical and surgical patients
- Length of treatment with vitamin K antagonists and prevention of recurrence in patients with venous thromboembolism
- Once versus twice daily injections of low molecular weight heparin for the initial treatment of blood clots in the veins
- Pentasaccharides for the treatment of deep vein thrombosis
- Pharmacomechanical thrombectomy for iliofemoral deep vein thrombosis
- Subcutaneous unfractionated heparin for the initial treatment of venous thromboembolism
- Thrombolysis for treatment of acute deep vein thrombosis
- Thrombophilia testing for the prevention of recurrent venous thromboembolism
- Treatment for superficial infusion thrombophlebitis of the upper extremity
- Treatment of below-the-knee deep vein thrombosis
- Vitamin K antagonists or low-molecular-weight heparin for long term treatment of symptomatic blood clots
- Warfarin initiation nomograms of 5 mg and 10 mg for venous thromboembolism
- HEART FAILURE (9)
- A breathing intervention for shortness of breath due to heart failure
- Antiplatelet versus anticoagulation treatment for patients with heart failure in sinus rhythm
- B-type natriuretic peptide-guided treatment for heart failure patients
- Digitalis for treatment of heart failure in patients in sinus rhythm
- Disease management programmes for heart failure
- Fluid removal therapy in acute heart failure
- Natriuretic peptide-guided treatment for preventing death and cardiovascular events among patients with risk factors for heart disease
- Nitrates for acute heart failure syndromes
- What is the evidence for the benefit and harms of anticoagulants for heart failure?
- HYPERTENSION (12)
- Antiplatelet agents and anticoagulants for high blood pressure (hypertension)
- Benefits of antihypertensive drugs for mild hypertension are unclear
- Beta-blockers for hypertension
- Blood pressure targets in people with cardiovascular disease
- Calcium channel blockers versus other classes of drugs for hypertension
- Does using low-sodium salt substitutes (LSSS) instead of regular salt reduce blood pressure and heart disease risks, and is it safe?
- Partial agonists for the treatment of high blood pressure.
- Renin angiotensin system inhibitors versus other types of medicine for hypertension
- The use of lower blood pressure targets for people with hypertension
- Thiazides best first choice for hypertension
- What are the benefits and harms of diuretics given as a first treatment compared to other drug classes for hypertension (high blood pressure)?
- What are the effects of stopping blood pressure medications in older people?
- MYOCARDIAL ISCHEMIA/CORONARY DISEASE (15)
- Are stem cells taken from a person's bone marrow and delivered to their heart a safe and effective treatment following a heart attack?
- Benefits and harms of drug-eluting versus bare-metal stents in people with acute coronary syndrome
- Beta-blockers versus placebo or no intervention for patients with suspected or diagnosed myocardial infarction
- Coronary artery bypass surgery performed with versus without cardiac arrest and cardiopulmonary bypass in patients with ischaemic heart disease
- Delivering clot-busting therapy before reaching hospital or in hospital to help people who are having heart attacks
- Does hyperbaric oxygen therapy improve outcome after heart attack?
- Drugs used as add-on therapy to heart procedure following heart attack
- Inotropic and vasodilator strategies in people with cardiogenic shock or low cardiac output
- Intra-aortic balloon counterpulsation in patients with acute myocardial infarction and cardiogenic shock
- Platelet glycoprotein IIb/IIIa blockers during percutaneous coronary intervention and as the initial treatment of acute coronary syndromes
- Prophylactic lidocaine for myocardial infarction
- Routine invasive versus conservative strategies for unstable angina and non-ST elevation myocardial infarction in the stent era
- Routine use of oxygen in people who have had a heart attack
- Treatments for depression in individuals with coronary artery disease
- Xiongshao capsule preventing restenosis after percutaneous coronary intervention in patients with coronary heart disease
- HEART AND CIRCULATION-OTHER (24)
- Antithrombin III for critically ill patients
- Are direct oral anticoagulants (a type of 'blood thinner') better than traditional anticoagulants for treating a pulmonary embolism (a blood clot in the lung)?
- Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children
- Colloids or crystalloids for fluid replacement in critically ill people
- D-dimer for excluding pulmonary embolism in hospital outpatient and accident and emergency populations
- Drugs to dissolve pulmonary embolism (blood clot in the lungs)
- Endovascular treatment for ruptured abdominal aortic aneurysm
- Extracorporeal (external to the body) membrane oxygenation (ECMO) for critically ill adults
- Fludrocortisone for the treatment of orthostatic hypotension
- Fluids for hydration in children
- Giving glutamine supplements to critically ill adults
- Hormone treatment may be ineffective in treating people with viral myocarditis
- Immunoglobulin treatment for Kawasaki disease
- Inotropic and vasodilator strategies in people with cardiogenic shock or low cardiac output
- Is home or hospital treatment better for people with blood clots in the lungs?
- Loop diuretics cause modest blood pressure lowering
- Mechanical heart pumps to aid a heart that fails suddenly
- Minimally invasive treatments to dissolve blood clots in the lungs (acute pulmonary embolism)
- Surgery for small abdominal aortic aneurysms that do not cause symptoms
- Systematic review of randomised controlled trials about the efficacy and safety of colchicine in people with pericarditis
- Treatment for superficial thrombophlebitis of the leg
- Use of fibrinogen concentrate in patients with bleeding
- Vasopressors for hypotensive shock
- Vena caval filters for the prevention of pulmonary embolism
- VASCULAR DISEASES PERIPHERAL AND CENTRAL ACCESS - SHOCK (10)
- Central venous access sites to prevent venous blood clots, blood vessel narrowing, and infection
- Controlled hypotension versus normotensive resuscitation strategy for people with ruptured abdominal aortic aneurysm
- Do blood thinners prevent blood clots in children who are treated using central lines?
- Does heparin locking prevent blocking of central venous catheters in adults when compared to locking with normal saline?
- Drug treatment for small abdominal aortic aneurysms
- Drugs to break down blood clots for people with sudden onset peripheral arterial occlusion
- Intravenous naftidrofuryl for treating critical limb ischaemia
- Is ultrasound guidance a good option for peripheral intravenous cannulation in adults?
- Surgery versus thrombolysis for the initial management of acute limb ischaemia
- Treatment for superficial thrombophlebitis of the leg
- ARYTHMIA (8)
- GYNECOLOGY - PREGNANCY AND CHILD BIRTH (53)
- Anaesthesia or analgesia during the manual removal of a retained placenta
- Anti-D administration after spontaneous miscarriage for preventing Rhesus alloimmunisation
- Antibiotics for mastitis in breastfeeding women
- Antibiotics for rupture of membranes when a pregnant women is at or near term but not in labour
- Antibiotics for treating bacterial vaginosis in pregnancy
- Antifibrinolytic drugs to treat heavy bleeding after childbirth
- Antifibrinolytics (such as tranexamic acid) for treatment of heavy menstrual bleeding
- Antiplatelet agents for preventing pre-eclampsia and its complications
- Antispasmodics for labour
- Are medicines that delay the start of labour (tocolytics) effective for delaying preterm birth?
- Are non-steroidal anti-inflammatory drugs safe and effective for treating heavy menstrual bleeding?
- Calcium channel blockers for inhibiting preterm labour and birth
- Carbetocin for preventing postpartum haemorrhage
- Cervical assessment by ultrasound for preventing preterm delivery
- Combinations of tocolytic drugs for inhibiting preterm labour
- Duration of treatment for asymptomatic bacteriuria during pregnancy
- Early skin-to-skin contact for mothers and their healthy newborn infants
- Inhaled analgesia for relieving pain during labour
- Interventions for nausea and vomiting in early pregnancy
- Interventions for treating severe nausea and vomiting during pregnancy (hyperemesis gravidarum)
- Intravenous fluids for preventing prolonged labour in women giving birth to their first baby
- Is it safer to deliver a baby immediately or wait if the mother has high blood pressure after 34 weeks of pregnancy that is not persistently severe?
- Management of intussusception in children
- Mechanical and surgical interventions for treating women with severe bleeding after childbirth
- Medical therapies for treating heavy menstrual bleeding in women with bleeding disorders
- Medications for reducing contractions during labour for excessively strong/frequent contractions or where the unborn baby is thought to be distressed
- Methods of emergency contraception
- Newborn resuscitation training programmes for improving the health and survival of newborns
- Non-opioid drugs for managing pain in labour
- Nonsteroidal anti-inflammatory drugs for dysmenorrhoea
- Nonsteroidal anti-inflammatory drugs for management of pain in women with endometriosis
- Oxytocin for preventing postpartum haemorrhage in non-facility birth settings
- Oxytocin injected into a vein or muscle for reducing blood loss after vaginal birth
- Oxytocin receptor antagonists for inhibiting preterm labour
- Paracetamol (acetaminophen) for prevention or treatment of pain in newborns
- Paracetamol for relief of perineal pain after birth
- Repeated use of hormonal drugs right before or after sex to prevent pregnancy
- Routine vaginal examinations in labour
- Scanning imaging techniques for the exclusion of pulmonary embolism during pregnancy
- Selective versus routine use of episiotomy for vaginal birth
- Specialist teams for neonatal transport to neonatal intensive care units for prevention of morbidity and mortality
- Terbutaline pump maintenance therapy after threatened preterm labour for reducing adverse neonatal outcomes
- The effectiveness of blood testing in the management of pyelonephritis in pregnancy for improving outcomes
- The risk of heart attack and stroke in women using birth control pills
- The use of respiratory support without endotracheal tube (i.e. non-invasive) in babies to manage rapid breathing (transient tachypnea of the newborn)
- Tocolytics for preterm premature rupture of membranes
- Treatment for excessive bleeding after childbirth
- Treatments for preventing and treating low-back and pelvic pain during pregnancy
- Uterine massage for preventing postpartum haemorrhage
- What are the benefits and risks of giving corticosteroids to pregnant women at risk of premature birth?
- What are the benefits and risks of tranexamic acid for preventing heavy bleeding after vaginal birth?
- Which drug is best for treating excessive bleeding after childbirth?
- Which medication is best for reducing excessive blood loss after childbirth and has the fewest unwanted effects?Updated
- INFECTIOUS DISEASES (98)
- ANTIBIOTICS (4)
- A single beta lactam antibiotic versus a beta lactam-aminoglycoside combination for patients with severe infection
- Alternative dosing strategies for intravenous antibiotics to treat severe infections
- Antibiotic treatment for asymptomatic bacteriuria
- Antibiotics to treat suspected cases meningitis due to infection with meningococcus before confirmation of diagnosis
- COVID-19 (32)
- Are antibiotics an effective treatment for COVID-19 and do they cause unwanted effects?
- Are corticosteroids (anti-inflammatory medicines) given orally or by injection an effective treatment for people with COVID-19?
- Are digital contact tracing technologies effective during infectious disease outbreaks?
- Are inhaled corticosteroids an effective treatment for people with mild COVID-19?
- Are laboratory-made COVID-19-specific monoclonal antibodies effective to prevent COVID-19 in adults?
- Are laboratory-made, COVID-19-specific monoclonal antibodies an effective treatment for COVID-19?
- Are medicines that block interleukin‐1 (a protein involved in immune responses) effective treatments for COVID‐19 and do they cause unwanted effects?
- Are systemic Janus kinase inhibitors an effective treatment for people with COVID-19?
- Can international travel-related control measures contain the spread of the COVID-19 pandemic?
- Chances of developing blood clots for people who have COVID-19 and are taking hormonal birth control compared to people not taking hormonal birth control
- Do blood thinners prevent people who are hospitalised with COVID-19 from developing blood clots?
- Factors that influence whether healthcare workers follow infection prevention and control guidelines for respiratory infectious diseases
- Fluvoxamine for treating COVID-19
- How accurate are rapid antigen tests for diagnosing COVID-19?
- How accurate are routine laboratory tests for diagnosis of COVID-19?
- How accurate are symptoms and medical examination to diagnose COVID-19?
- How accurate is chest imaging for diagnosing COVID-19?
- How effective is screening for COVID-19?
- Immunity in vulnerable groups after COVID-19 vaccination
- Interventions for the treatment of persistent smell disorders (olfactory dysfunction) after COVID-19 infection
- Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus?
- Is colchicine an effective treatment for people with COVID-19?
- Is plasma from the blood of people who have recovered from COVID-19 an effective treatment for other people with COVID-19?
- Is the combination of nirmatrelvir plus ritonavir effective for treating or preventing COVID-19?
- Is vitamin D an effective and safe treatment for COVID-19?
- Ivermectin for preventing and treating COVID-19
- Prophylactic blood thinners for the prevention of death and venous thromboembolism in COVID-19 outpatients
- Protective clothes and equipment for healthcare workers to prevent them catching coronavirus and other highly infectious diseases
- Remdesivir to treat people with COVID-19
- What is the diagnostic accuracy of antibody tests for the detection of infection with the COVID-19 virus?
- What type of heart and blood vessel problems complicate COVID-19 infections, how common are they and what other medical conditions do these patients have?
- Which treatments are best for symptoms in COVID-19 patients at the end of life?
- HIV/AIDS (2)
- INFECTIOUS DISEASES-OTHER (35)
- Adjustment of antimicrobial agents for adults with sepsis, severe sepsis or septic shock
- Antibiotic therapy for the treatment of methicillin-resistant Staphylococcus aureus (MRSA)-infected or colonised non surgical wounds
- Antibiotics for covert bacteriuria in children
- Antibiotics for the common cold, an infection of the upper respiratory tract
- Antibiotics for the treatment of leptospirosis
- Antibiotics for treating human brucellosis
- Antibiotics to treat suspected cases meningitis due to infection with meningococcus before confirmation of diagnosis
- Antiepileptic drugs for the primary and secondary prevention of seizures in viral encephalitis
- Antihistamines for the common cold
- Automated monitoring for the early detection of sepsis in patients receiving care in intensive care units
- Bathing critically ill patients with chlorhexidine to prevent hospital-acquired infections
- Corticosteroids for the treatment of parasitic eosinophilic meningitis
- Corticosteroids for treating sepsis
- Different fluid therapy strategies for sepsis and septic shock
- Echinacea for preventing and treating the common cold
- Garlic for the common cold
- Heated, humidified air for the common cold
- How accurate are nucleic and antigen detection tests in diagnosing leptospirosis?
- Human recombinant activated protein C for severe sepsis and septic shock in adult and paediatric patients
- Intravenous immunoglobulins for treating patients with severe sepsis and septic shock
- Intravenous N-acetylcysteine compared to placebo for treatment of systemic inflammatory response syndrome and sepsis in seriously ill adults
- Levels of interleukin-6 in identifying severely ill adult patients with sepsis
- Non-steroidal anti-inflammatory drugs for the common cold
- Oral antihistamine-decongestant-analgesic combinations for the common cold
- Procalcitonin evaluation for reducing mortality in adults with sepsis
- Rapid diagnostic tests for plague
- Smectite for treating children with acute diarrhoea
- Steroids for short-term symptom control in infectious mononucleosis (glandular fever)
- Steroids for the common cold
- Substituting or adding fluoroquinolones to established first-line antituberculous drug regimens gives no additional benefit or risks
- The accuracy of rapid diagnostic tests for detecting typhoid and paratyphoid (enteric) fever
- The effect of short duration versus standard duration antibiotic therapy for streptococcal throat infection in children
- Use of corticosteroids for treatment of the newborn with bacterial meningitis
- Vitamin C for preventing and treating tetanus
- Vitamin C for preventing and treating the common cold
- INFLUENZA (6)
- Amantadine and rimantadine to prevent and treat influenza A in children and the elderly
- Chinese medicinal herbs for influenza
- Homeopathic Oscillococcinum® for preventing and treating influenza and influenza-like illness
- Neuraminidase inhibitors for preventing and treating influenza in children
- Regulatory information on trials of oseltamivir (Tamiflu) and zanamivir (Relenza) for influenza in adults and children
- Steroids for the treatment of influenza
- SEXUALLY TRANSMITTED DISEASES (3)
- TROPICAL DISEASES (16)
- Administering antimalarial drugs to prevent malaria in infants
- Antibiotics for treating cholera
- Antipyretic measures for treating fever in malaria
- Artemether injection for treating people with severe malaria
- Artemisinin-based combination therapy (ACT) for treating non-severe malaria due to Plasmodium vivax
- Artemisinin-naphthoquine for treating uncomplicated Plasmodium falciparum malaria
- Artesunate reduces death from severe malaria
- Can mefloquine prevent malaria during travel to areas where the disease is widespread?
- Corticosteroids for treating dengue infection in children and adults
- Mefloquine for preventing malaria in pregnant women
- Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria
- Rapid diagnostic tests for visceral leishmaniasis
- Rapid diagnostic tests versus clinical diagnosis for managing fever in settings where malaria is common
- Rapid tests for diagnosing malaria caused by in people living in areas where malaria is very common
- Rapid tests for diagnosing malaria caused by Plasmodium vivax or other less common parasites
- What are the benefits and risks of atovaquone-proguanil for treating uncomplicated malaria caused by the Plasmodium falciparum parasite?
- ANTIBIOTICS (4)
- LUNGS AND AIRWAYS (110)
- ASTHMA (31)
- Addition of intravenous beta2-agonists to inhaled beta2-agonists for acute asthma
- Anti-leukotriene agents compared to inhaled corticosteroids for people with asthma
- Anticholinergic therapy for acute asthma in children
- Are antibiotics a safe and effective additional treatment for asthma exacerbations?
- Are inhaled anticholinergics added to β2-agonists beneficial in children hospitalised with acute asthma?
- Asthma reliever inhalers (beta2-agonists) used for exercise-induced asthma and exercise-induced bronchoconstriction
- Can exhaled nitric oxide be used to adjust asthma medications in children with asthma?
- Combined beta-agonists and anticholinergics compared to beta-agonists alone for adults with asthma treated in emergency departments
- Different doses and durations of oral steroids for asthma attacks
- Do magnesium sulfate infusions reduce the need for hospital admission in adults with acute asthma?
- Do magnesium sulfate infusions reduce the need for hospital admission in children with acute asthma?
- Does adding antileukotriene agents to usual care when people are suffering an asthma attack in the emergency department help?
- Does an aminophylline injection in addition to bronchodilators for an asthma attack improve lung function and other outcomes or cause harm?
- Early use of inhaled corticosteroids in the emergency department treatment of acute asthma
- Holding chambers (spacers) versus nebulisers for delivery of beta-agonist relievers in the treatment of an asthma attack
- In people with asthma are single inhalers that contain both formoterol and budesonide better than current best practice?
- Increasing the dose of inhaled steroids or continuing the usual dose to treat asthma attacks in adults and children
- Inhaled corticosteroids for acute asthma following emergency department discharge
- Interventions for acute severe asthma attacks in children: an overview of Cochrane Reviews
- Interventions for managing asthma in pregnancy
- Intramuscular versus oral corticosteroids for acute asthma
- Intravenous beta2-agonists and intravenous aminophylline for acute asthma
- Is inhaled magnesium sulfate a safe and effective treatment for people with asthma attacks?
- Is taking inhaled corticosteroids only when asthma symptoms get worse as safe and effective as taking inhaled corticosteroids every day?
- Non-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbations of asthma
- Oral corticosteroid treatment started by patients or parents during a severe asthma attack
- Regular treatment with formoterol and inhaled steroids for chronic asthma: serious adverse events
- Role of ketamine for management of acute severe asthma in children
- Sublingual immunotherapy for asthma
- Vaccines for preventing flu in people with asthma
- Vitamins C and E for asthma and exercise-induced breathlessness
- COPD (18)
- Airway clearance techniques for chronic obstructive pulmonary disease
- Are antibiotics beneficial for flare-ups of chronic obstructive pulmonary disease?
- Are shorter courses of systemic steroids as effective as conventional longer courses in the treatment of patients with flare-ups of COPD?
- Are tiotropium plus combination inhalers better than tiotropium or combination inhalers alone for the treatment of COPD?
- Combined inhalers compared to tiotropium inhalers for the treatment of chronic obstructive pulmonary disease
- Combined inhalers versus placebo for the treatment of chronic obstructive pulmonary disease (COPD)
- Do people recover from exacerbations of chronic obstructive pulmonary disease (COPD) better in their own home than in the hospital emergency room?
- Do systemic corticosteroids improve treatment outcomes in flare-ups of chronic obstructive pulmonary disease?
- In stable COPD, should inhaled corticosteroids be used with combination long-acting beta2-agonist/long-acting muscarinic antagonist inhalers?
- Inhaled corticosteroids compared with placebo for stable chronic obstructive pulmonary disease (COPD)
- Is magnesium sulfate effective for chronic obstructive pulmonary disease (COPD) flare-ups?
- Long-acting beta2-agonists for people with COPD
- Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease
- Non-invasive ventilation for people with respiratory failure due to exacerbation of chronic obstructive pulmonary disease (COPD)
- Oxygen therapy in the pre-hospital setting for sudden worsening of chronic obstructive pulmonary disease
- Prophylactic antibiotics for people with COPD
- Tiotropium for managing COPD
- Tiotropium versus ipratropium bromide in the management of COPD
- LUNGS AND AIRWAYS-OTHER (61)
- A gentler form of mechanical breathing for people affected by severe lung failure
- Acetylcysteine and carbocysteine to treat acute upper and lower respiratory tract infections in children without chronic broncho-pulmonary disease
- Airway clearance techniques in bronchiectasis
- Antibiotic treatment for people with acute bronchitis
- Antibiotic treatment for Stenotrophomonas maltophilia in people with cystic fibrosis
- Antibiotics for bronchiolitis in children under two years of age
- Antibiotics for common respiratory infections with unclear causes and undifferentiated symptoms in children up to five years of age
- Antibiotics for community-acquired pneumonia in adolescent and adult outpatients
- Antibiotics for persistent cough or wheeze following acute bronchiolitis in children
- Antibiotics to treat respiratory infections caused by the bacteria Mycoplasma pneumoniae in children
- Anticoagulant treatment for subsegmental pulmonary embolism
- Antifibrinolytic therapy to reduce haemoptysis
- Approaches to guiding oxygen therapy in adult intensive care patients with acute respiratory distress syndrome
- Azithromycin for acute lower respiratory tract infections
- Beta2-agonist drugs for treating cough or a clinical diagnosis of acute bronchitis
- Bronchodilators for bronchiolitis for infants with first-time wheezing
- Can tests for inflammation help doctors decide whether to use antibiotics for airway infections?
- Chest physiotherapy for acute bronchiolitis in children younger than two years of age
- Chest physiotherapy for pneumonia in adults
- Chest X-rays in acute chest infections
- Chinese herbs combined with Western medicine for treating severe acute respiratory syndrome (SARS)
- Clinical symptoms and signs for the diagnosis of Mycoplasma pneumoniae in children and adolescents with community-acquired pneumonia
- Comparing treatment of non-severe pneumonia, in children aged 2 to 59 months, with and without antibiotics
- Continuous negative extrathoracic pressure or continuous positive airway pressure for children with acute respiratory failure and shortage of oxygen
- Continuous positive airway pressure (CPAP) for acute bronchiolitis in children
- Delayed antibiotic prescriptions for respiratory tract infections
- Different antibiotics for community-acquired pneumonia in otherwise healthy children younger than 18 years of age in hospital and outpatient settings
- Drugs to treat acute respiratory distress syndrome in adults
- Elective (regular) versus symptomatic intravenous antibiotic therapy for cystic fibrosis
- Embolisation therapy for pulmonary arteriovenous malformations
- Glucocorticoids for acute viral bronchiolitis in infants and young children under two years of age
- Heliox inhalation therapy for bronchiolitis in infants
- High-frequency oscillation for the treatment of acute respiratory distress syndrome (ARDS)
- Higher or lower levels of oxygen for adults admitted to the intensive care unit
- Honey for acute cough in children
- How accurate is chest ultrasonography compared to supine chest radiography for diagnosis of traumatic pneumothorax in the emergency department?
- Inhaled corticosteroids for subacute cough in children
- Interventions for the management of fluid around the lungs (pleural fluid) caused by cancer
- Intravenous fluids compared to nasogastric or orogastric tube hydration for children hospitalised with bronchiolitis
- Is treatment with corticosteroids beneficial and safe for people with pneumonia?
- Is vitamin D an effective and safe addition to antibiotics for treating children with acute pneumonia?
- Leukotriene inhibitors for bronchiolitis in infants and young children
- Low blood oxygen levels versus normal blood oxygen levels in ventilated severely ill people
- Observation alone versus drain tube or needle insertion (interventional) for primary spontaneous pneumothorax in adults without previous lung disease.
- Over-the-counter medications to help reduce cough for children and adults on antibiotics for acute pneumonia
- Oxygen therapy as part of the treatment for respiratory infections in children
- Partial liquid ventilation for mechanical ventilation of severely ill children with acute lung injury and acute respiratory distress syndrome
- Positioning for hospitalised infants and children with acute respiratory distress
- Positive airway pressure for heart failure associated with central sleep apnoea
- Probiotics for preventing ventilator-associated pneumonia
- Prone (face-down) position for mechanical ventilation of adults with acute respiratory failure
- Rapid viral testing for children in the Emergency Department with fever and respiratory symptoms
- Recruitment manoeuvres as a ventilation strategy for adults with acute respiratory failure due to lung injury
- Short-course versus long-course antibiotic treatment for hospital-acquired pneumonia in adult intensive care patients
- Simple aspiration versus intercostal tube drainage for primary spontaneous pneumothorax in adults
- Testing blood procalcitonin levels to decide when to start and stop antibiotics in adults with acute respiratory tract infections
- The effectiveness of oxygen for adult patients with pneumonia
- Treatment of the cough in whooping cough
- Use of inhaled nitric oxide in patients with acute respiratory failure with low blood oxygen does not improve survival
- Vitamin C for preventing and treating pneumonia
- What are the benefits and risks of hypertonic saline solution via nebuliser for treating infants with acute bronchiolitis, compared to normal saline solution?
- ASTHMA (31)
- MENTAL HEALTH (30)
- DEPRESSION - ANXIETY (2)
- MENTAL HEALTH-OTHER (23)
- Antidepressants for agitation and psychosis in dementia
- Antipsychotic drugs for elderly people with late-onset schizophrenia
- Aripiprazole alone or in combination with other drugs for treating the acute mania phase of bipolar disorder
- Benzodiazepines alone or in combination with antipsychotic drugs for acute psychosis
- Benzodiazepines for panic disorder in adults
- Benzodiazepines for schizophrenia
- Cognitive-behavioural treatments for non-cardiac chest pain
- Crisis intervention for people with severe mental illnesses
- Crisis interventions for people with borderline personality disorder
- Do antipsychotic medicines reduce agitated behaviour and psychotic symptoms in people with Alzheimer's disease and vascular dementia?
- Haloperidol as a means of calming people who are aggressive or agitated due to psychosis
- Haloperidol dose for the acute phase of schizophrenia
- How effective is aripiprazole for calming people who are aggressive or agitated due to psychosis?
- Intervention to prevent delirium for critically ill patients in the intensive care unit (ICU)
- Interventions for preventing and reducing the use of physical restraints of older people in hospital
- Medicines to treat delirium in critically ill adult patients
- Melatonin to improve sleep in the intensive care unit
- Opioids for agitation in dementia
- Risperidone as a means of calming people who are aggressive or agitated due to psychosis
- The use of benzodiazepines to treat adults with delirium, excluding patients being cared for in intensive care units (ICU)
- Treatment of epilepsy for people with Alzheimer's disease
- Treatments for delusional disorder
- Valproate preparations for the treatment of agitated behaviour in people with dementia
- POST-TRAUMATIC STRESS DISORDER (5)
- Medication for posttraumatic stress disorder
- Medicines for preventing post-traumatic stress disorder (PTSD)
- Multiple session early psychological interventions for prevention of post-traumatic stress disorder
- Present-centered therapy (PCT) for post-traumatic stress disorder (PTSD) in adults
- Psychological therapies for the treatment of post-traumatic stress disorder in children and adolescents
- NEUROLOGY (94)
- EPILEPSY (13)
- Anticonvulsant therapy for status epilepticus
- Antiepileptic drugs versus no treatment or placebo for children with benign epilepsy with centro temporal spikes
- Calcium antagonists as an add-on therapy for drug-resistant epilepsy
- Clonazepam add-on therapy for drug-resistant epilepsy in adults and children
- Drug management for acute tonic-clonic convulsions (fits), including convulsive status epilepticus in children
- Immediate antiepileptic drug treatment, versus placebo, deferred, or no treatment for first unprovoked seizure
- Ketogenic diets for drug-resistant epilepsy
- Lamotrigine add-on therapy for drug-resistant focal epilepsy
- Lamotrigine as add-on therapy for drug-resistant generalised tonic-clonic seizures
- Phenobarbitone versus phenytoin monotherapy (single-drug treatment) for epilepsy
- Prophylactic drug management for febrile seizures in children
- Propofol versus thiopental sodium for the treatment of refractory status epilepticus (RSE)
- Treatments to prevent Sudden Unexpected Death in Epilepsy (SUDEP)
- MIGRAINE (13)
- Aspirin with or without an antiemetic for acute migraine headaches in adults
- Diclofenac with or without an antiemetic for acute migraine headaches in adults
- Drugs for the acute treatment of migraine in children and adolescents
- How effective are medicines used to treat attacks of vestibular migraine?
- Ibuprofen with or without an antiemetic for acute migraine headaches in adults
- Naproxen for acute migraine in adults
- Normal pressure oxygen therapy and hyperbaric oxygen therapy for migraine and cluster headaches
- Oral aspirin for treatment of acute episodic tension-type headache in adults
- Paracetamol (acetaminophen) with or without an antiemetic for acute migraine in adults
- Sumatriptan (oral route of administration) for acute migraine attacks in adults
- Sumatriptan (subcutaneous route of administration) for acute migraine attacks in adults
- Sumatriptan plus naproxen for acute migraine attacks in adults
- Zolmitriptan for acute migraine attacks in adults
- NEUROLOGY-OTHER (30)
- Antibiotics for preventing meningococcal infections
- Aspirin, steroid and non-steroidal anti-inflammatory drugs use for treating Alzheimer's disease
- Baseline scores of Mini-Mental State examination (MMSE) for early prediction of developing dementia in people with mild cognitive impairments (MCI)
- Betahistine for symptoms of vertigo
- Corticosteroids for bacterial meningitis
- Dopamine agents for hepatic encephalopathy
- Drug treatment for pain in Guillain-Barré syndrome
- Drug treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for acute Guillain Barré syndrome
- Drugs for preventing headache after a lumbar puncture
- Drugs for treating headache after a lumbar puncture
- Endothelin receptor antagonists for subarachnoid hemorrhage
- Fluids for people with acute bacterial meningitis
- Gabapentin for chronic neuropathic pain in adults
- High pressure (hyperbaric) oxygen therapy for Bell's palsy
- Interventions to prevent delirium in hospitalised patients, not including those on intensive care units
- Intravenous immunoglobulin for myasthenia gravis
- Jolt accentuation of headache as a test for acute meningitis in emergency settings
- Medical and surgical treatment for ocular myasthenia
- Non-drug approaches for preventing delirium in adults receiving care in hospital outside of intensive care and high dependency units
- Oral ibuprofen for acute treatment of episodic tension-type headache in adults
- Oral ketoprofen for treatment of acute episodic tension-type headache in adults
- Oral paracetamol for treatment of acute episodic tension-type headache in adults
- Osmotic therapies added to antibiotics for acute bacterial meningitis
- Paracetamol (acetaminophen) alone, or in combination with codeine or dihydrocodeine, for neuropathic pain in adults
- Patch angioplasty versus primary closure for carotid endarterectomy
- Plasma exchange for chronic inflammatory demyelinating polyradiculoneuropathy
- Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) for preventing tension-type headache
- The use of computed tomography angiography (CTA) to confirm the clinical diagnosis of brain death
- Treatments to help blood clotting to improve the recovery of adults with stroke due to bleeding in the brain
- Triptans for acute cluster headache
- STROKE AND TRANSIENT ISCHEMIC ATTACK (38)
- Accuracy of prehospital stroke scales to identify people with stroke or transient ischemic attack (TIA)
- Acupuncture for acute stroke
- Antibiotic therapy for preventing infections in people with acute stroke
- Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage
- Beta-blockers for preventing stroke recurrence
- Buflomedil for acute ischaemic stroke
- Calcium antagonists for acute ischemic stroke
- Cerebrolysin for acute ischaemic stroke
- Clot-dissolving drugs (different doses, routes of administration and agents) for breaking down a blood clot blocking a blood vessel in the brain
- Clot-dissolving drugs for treating ischaemic stroke in the early stages
- Computed tomography angiography or magnetic resonance angiography for detecting blood vessel abnormalities in patients with intracerebral haemorrhage
- Continuous or intermittent monitoring of people with acute stroke
- Controlling high blood sugar levels with insulin in people who have had an acute ischaemic stroke
- Does the type of anaesthesia for recanalisation therapies for acute ischaemic stroke affect patient outcomes?
- Drug interventions for deliberately altering blood pressure in acute stroke
- Drugs for reducing iron in people with acute stroke
- Early treatment with blood-thinning drugs for people who have had a stroke
- Early versus delayed mobilisation to prevent further bleeding after spontaneous bleeding on the surface of the brain
- Endovascular therapy versus conventional medical treatment for symptomatic intracranial artery stenosis
- External counterpulsation for acute ischaemic stroke
- Fibrinogen depleting agents may help to remove blood clots in acute ischaemic stroke
- Gamma aminobutyric acid (GABA) receptor agonists for acute stroke
- Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke
- Haemodilution for acute ischaemic stroke
- Hyperbaric oxygen therapy for treating people with acute ischaemic stroke
- Mailuoning (a type of traditional Chinese medicine) for improving outcome in people with acute ischaemic stroke
- Non-pharmacological interventions for preventing secondary vascular events after stroke or transient attack
- Oral antiplatelet therapy for acute ischaemic stroke
- Organised inpatient (stroke unit) care
- Piracetam for acute ischaemic stroke
- Recanalisation therapies for wake-up stroke
- Surgical decompression for cerebral oedema in acute ischaemic stroke
- Swallowing therapy for difficulties with swallowing in stroke survivors who have had a recent stroke
- Transcranial colour Doppler (TCD) and transcranial colour-coded duplex (TCCD), in patients with acute ischaemic stroke for detecting intracranial vessel occlusion or stenosis
- Treatments through the artery versus clot-dissolving drugs for the early treatment of stroke
- Ultrasound (high-frequency sound waves) plus a clot-busting drug for breaking down a blood clot blocking a blood vessel in the brain
- Use of multiple versus fewer antiplatelet drugs for preventing early recurrence after stroke or transient ischaemic attack
- Which types of blood-thinning drugs (anticoagulants) are best to prevent blood clots in people soon after stroke?
- EPILEPSY (13)
- OPHTALMOLOGY (8)
- Corticosteroid eye drops used in addition to standard antibiotic therapy in the treatment of bacterial keratitis
- Interventions for an acute internal hordeolum
- Medical treatment for traumatic hyphema
- Steroids in the treatment of traumatic optic neuropathy
- Topical non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of pain in traumatic corneal abrasions
- Treatments for acute central retinal artery occlusion (blockage of the blood supply to the retina of the eye)
- Valacyclovir compared with acyclovir for the treatment of herpes zoster ophthalmicus in people with an otherwise normal immune system
- What are the benefits and harms of antibiotics for acute bacterial conjunctivitis?
- PEDIATRICS (15)
- Alternating and combined antipyretics for treatment of fever in children
- Best position for newborns who need assisted ventilation
- Beta-blockers for children with congestive heart failure
- Can breathing support using continuous positive airway pressure (CPAP), given within the first hour of life, prevent death and illness in premature babies?
- Chest physiotherapy for acute bronchiolitis in children younger than two years of age
- Continuous positive airways pressure for respiratory distress in preterm infants
- Cuffed versus uncuffed endotracheal tubes for neonates
- Early versus delayed initiation of continuous positive airway pressure (CPAP) for respiratory distress in preterm infants
- High-flow nasal cannula (tube) oxygen therapy for infants with bronchiolitis
- Opioids for managing pain in babies exposed to painful procedures
- Probiotics for the management of functional abdominal pain disorders in children
- Racecadotril to treat children under five years of age with acute diarrhoea
- The aspiration of pneumothorax in the newborn with a small needle compared to a larger tube placed through the intercostal space
- Using corticosteroids to treat Kawasaki disease
- What are the benefits and risks of hypertonic saline solution via nebuliser for treating infants with acute bronchiolitis, compared to normal saline solution?
- RHEUMATOLOGY - NON TRAUMATIC OSTEO ARTICULAR PATHOLOGIES - MUSCULOSKELETEL DISORDERS (28)
- Anti-inflammatory drugs for acute low back pain
- Back schools for acute and subacute non-specific low-back pain
- Can tests for inflammation help doctors decide whether to use antibiotics for airway infections?
- Colchicine for treating acute gout flares
- Cold-water immersion for preventing and treating muscle soreness after exercise
- Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy
- Corticosteroids for Guillain-Barré syndrome
- Deep transverse friction massage for the treatment of lateral elbow or lateral knee tendinitis
- Diagnostic tests for assessing rotator cuff tears in people with shoulder pain for whom surgery is being considered
- Exercise for Neck Pain
- Image-guided versus blind glucocorticoid injection for shoulder pain
- Interleukin-1 inhibitors for acute gout
- Intravenous immunoglobulin for Guillain-Barré syndrome
- Local steroid injection for carpal tunnel syndrome
- Manipulation and mobilisation for neck disorders
- Muscle energy technique (MET) for non-specific low-back pain
- Non-steroidal anti-inflammatory drugs (NSAIDs) for acute gout
- Non-steroidal anti-inflammatory drugs (NSAIDs) for treating tennis elbow pain in adults
- Non-steroidal anti-inflammatory drugs for low back pain with sciatica
- Pain in patients with inflammatory arthritis and gastrointestinal or liver problems
- Paracetamol for low back pain
- Paracetamol for treating people with hip or knee osteoarthritis
- Patient education for neck pain
- Physician use of red flags to screen for cancer in patients with new back pain
- Physician use of red flags to screen for fractured vertebrae for patients with new back pain
- Plasma exchange for Guillain-Barré syndrome
- Systemic corticosteroids for radicular and non-radicular low back pain
- What are the likely benefits and harms of non-medicine and non-surgical treatments for non-specific low back pain?
- SKIN AND ALLERGY (10)
- Adrenaline auto-injectors for the treatment of anaphylaxis in the community
- Antibiotic drugs for treating skin and soft tissue infections
- Effects of antihistamines on eczema
- Glucocorticoids for the treatment of anaphylaxis
- H1-antihistamines for chronic spontaneous urticaria
- Helminth therapy (worms) for allergic rhinitis
- Histamine-blocking drugs for hives
- Ivermectin and permethrin for treating scabies
- Using oxygen at high pressure (in a compression chamber) for the treatment of individuals with severe soft tissue infection (necrotizing fasciitis)
- What are the benefits and risks of different treatments for bacterial folliculitis and boils (inflammation of the skin around hairs)?
- TECHNICAL PROCEDURES (43)
- INTUBATION AND VENTILATION (17)
- Comparison of different techniques for planned opening of the trachea
- Comparison of video-assisted and non-video-assisted devices for intubation of children
- Cuffed versus uncuffed tubes in children aged eight years and under, having general anaesthetic
- Do ventilators that manage the reduction of ventilator support (weaning) reduce the duration of weaning compared to strategies managed by clinicians?
- Do video-assisted instruments for inserting breathing tubes in adults work better than direct-view instruments and do they cause unwanted effects?
- Does the placement of a breathing tube using video assistance (videolaryngoscopy) increase the success and safety of the procedure in newborn babies?
- Drugs for preventing major morbidity and mortality related to blood pressure and heart rate changes associated with tracheal intubation
- Effect of applying cricoid pressure during rapid sequence induction of general anaesthesia
- Effects of higher versus lower levels of pressure in the lungs at the end of each breath during mechanical ventilation in patients with acute respiratory distress syndrome (ARDS)
- High-flow nasal cannulae for breathing support in adult intensive care patients
- Intubation methods for obese patients requiring general anaesthesia
- Laryngeal mask airway versus bag-mask ventilation or endotracheal intubation for neonatal resuscitation
- Methods for securing endotracheal tubes in newborn infants
- Nasal high flow therapy for breathing support in preterm babies
- SmartCare™ versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults
- Synchronised mechanical ventilation for respiratory support in newborn infants
- Use of noninvasive ventilation (a mask ventilator) holds promise as a method to make it easier to remove adults from conventional ventilators.
- TECHNICAL PROCEDURES-OTHER (22)
- Anaesthetic drugs for cardioversion
- Antibiotics at the time of removal of a central line to reduce complications in newborn infants
- Body position and intake of fluids for preventing headache after a lumbar puncture
- Central venous catheter coating with antiseptics or antibiotics for reducing catheter-related infections in adults
- Comparison of the different ways of giving fluids to patients who cannot drink enough, such as patients with Ebola virus disease
- Devices with safety features for preventing percutaneous exposure injuries in healthcare staff
- Does the speed of injection make a difference in the amount of pain and bruising in people receiving heparin injections?
- Dressings and securement for central venous catheters (CVCs)
- How often should dressings on central venous access devices (CVADs) be changed to reduce catheter-related infection?
- Hyperbaric oxygen therapy for acute surgical and traumatic wounds
- Lateral positioning for critically ill adult patients
- Loop diuretics for patients receiving blood transfusions
- Needle characteristics that reduce the occurrence of post-dural puncture headache (PDPH)
- Plasma transfusion strategies for critically ill patients
- Psychological strategies to reduce pain and distress for children and adolescents getting needles
- Radial artery versus femoral artery approach for performing coronary catheter procedures in people with coronary artery disease
- Replacing a peripheral venous catheter when clinically indicated versus routine replacement
- Skin antisepsis for reducing central venous catheter-related infections
- Topical treatment with a blood-clot promoting drug to reduce bleeding
- Use of adrenaline with lidocaine for surgery on fingers and toes
- Use of capnography in emergency department patients being sedated for procedures
- Use of platelet transfusions prior to a lumbar puncture or epidural anaesthetic in people with a low platelet count
- ULTRASOUND (4)
- Ultrasound guidance versus anatomical landmarks for internal jugular vein catheterization
- Ultrasound guidance versus anatomical landmarks for subclavian or femoral vein catheterization
- Ultrasound to guide arterial (other than femoral) punctures and cannulation in adults
- Ultrasound use for insertion of arterial catheters in children
- INTUBATION AND VENTILATION (17)
- TOBACCO, DRUGS AND ALCOHOL DEPENDENCE - ENVIRONMENTAL EMERGENCIES (11)
- ENVIRONMENTAL EMERGENCIES (3)
- Electric fans for reducing the health effects of heatwaves
- Snake antivenoms for treating people who have been bitten by a snake, and have developed abnormal blood clotting
- What are the benefits and risks of treating paraquat poisoning with a combination of steroids and cyclophosphamide (an anti-cancer medicine)?
- TOBACCO, DRUGS AND ALCOHOL DEPENDENCE (8)
- Alcohol has a biphasic effect on blood pressure and increases heart rate
- Baclofen for alcohol withdrawal syndrome
- Buprenorphine for managing opioid withdrawal
- Effects of perioperative alcohol cessation interventions on postoperative complications following surgery
- Interventions for paracetamol (acetaminophen) overdose
- Magnesium for the prevention or treatment of alcohol withdrawal syndrome in adults
- Motivational interviewing (MI) for preventing alcohol misuse in young adults is not effective enough
- Thiamine for prevention and treatment of Wernicke-Korsakoff syndrome in people who abuse alcohol
- ENVIRONMENTAL EMERGENCIES (3)
- TRAUMATOLOGY (83)
- BLEEDING (5)
- Blood-clot promoting drugs for acute traumatic injury
- Platelet transfusions treated to reduce transfusion-transmitted infections for the prevention of bleeding in people with low platelet counts
- Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia
- TEG and ROTEM for diagnosing trauma‑induced coagulopathy (disorder of the clotting system) in adult trauma patients with bleeding
- Varying the timing or the volume of intravenous fluids given to people with uncontrolled bleeding due to injury
- BURNS (6)
- FRACTURES (30)
- Antibiotics to prevent infection of the brain coverings (meningitis) in patients with basilar skull fracture
- Aspiration of the elbow joint for treating radial head fractures
- Comparing different types of scan (CT, MRI, bone scan) for diagnosis of clinically suspected scaphoid fractures, when initial radiographs are negative
- Conservative interventions for shaft fractures of the forearm bones in children
- Do local anaesthetic nerve blocks provide effective pain relief for adults with a hip fracture?
- Fixation devices secured across the fracture that are placed either directly or externally for treating hip fractures located outside the hip joint
- Hip replacement surgery in adults
- Interventions for treating adults with an isolated fracture of the ulnar shaft
- Intramedullary nails for extracapsular hip fractures in adults
- Nerve blocks for initial pain management of thigh bone fractures in children
- Non-surgical interventions for treating a broken collarbone in adolescents and adults
- Optimization of fluid levels in people suffering hip fractures
- Pedicle screw fixation methods for traumatic fractures of the thoracic and lumbar spine
- Rehabilitation as part of treatment for adults with a broken wrist
- Surgery or non-surgical treatments: which works better to treat people who have a dislocated knee cap?
- Surgical interventions for treating fractures of the olecranon (an elbow bone) in adults
- Surgical interventions for treating radial head fractures in adults
- Surgical versus conservative for treatment for acromioclavicular dislocations of the shoulder in adults
- Surgical versus conservative interventions for treating broken collarbones in adolescents and adults
- Surgical versus conservative treatment for ankle fractures in adults
- Surgical versus non-surgical interventions for treating humeral shaft fractures in adults
- Surgical versus non-surgical treatment for thoracolumbar burst fractures without neurological deficit
- Treatments for breaks in the lower part of the thigh bone in adults
- Treatments for broken ankles in children
- Treatments for broken kneecaps in adults
- Ultrasound and shockwave treatment for recently broken bones in adults
- Using oxygen at high pressure (in a compression chamber) for the treatment of broken bones
- What are the benefits and risks of treating broken heel bones with or without an operation?
- What are the best ways of treating adults with a fractured (broken) shoulder?
- Which approaches help with recovery after a broken ankle in adults?
- HEAD TRAUMA (9)
- Acupuncture for acute management and rehabilitation of traumatic brain injury
- Barbiturate drugs for people with traumatic brain injury
- Concentrated salt solution versus other treatments to lower pressure around the brain for people with acute traumatic brain injury
- Does hyperbaric oxygen therapy improve the survival and quality of life in patients with traumatic brain injury?
- Elevation of the head during intensive care management in people with severe traumatic brain injury
- Hypothermia (body temperature cooling) for people with an injury to the brain
- Partial removal of skull (decompressive craniectomy) to lower treatment-resistant high pressure in the skull and brain after traumatic brain injury
- Progesterone for traumatic brain injury
- The Lund concept in the treatment of brain injuries
- TRAUMATOLOGY-OTHER (26)
- Acupuncture for sudden-onset ankle sprains in adults
- Advanced training in trauma life support for ambulance crews
- Advanced training in trauma life support for hospital staff
- Antibiotics for injuries to the abdomen that break through the skin: which antibiotics are effective, and for how long should they be taken?
- Clinical tools for detecting cervical spine injury (CSI) in children with injuries
- Different methods of manipulation for reducing pulled elbow in young children
- How accurate is bedside ultrasound for the diagnosis of injuries to the abdomen or chest in patients with blunt injuries?
- Interventions for treating acute elbow dislocations in adults
- Is surgery or observation better for people who have a severe blunt injury to the liver?
- Low molecular weight heparin for prevention of venous thromboembolism in adults with lower-limb immobilization in an outpatient setting
- Non-surgical management after non-surgical repositioning of traumatic anterior dislocation of the shoulder
- Oral non-steroidal anti-inflammatory drugs compared with other oral pain killers for sprains, strains and bruises
- Platelet-rich therapies for musculoskeletal soft tissue injuries
- Regular or selected use of computed tomography (CT) scanning to reduce deaths in people who have a high-energy blunt-traumatic injury
- Rehabilitation following an injury to the hamstring in adults
- Should prophylactic antibiotics be used in patients with penetrating abdominal trauma?
- Splints and other non-surgical methods for treating common injuries of the middle joints of the fingers
- Steroids for acute spinal cord injury
- Surgery for unstable trauma patients
- Surgery or non-surgical treatments: which works better to treat people who have a dislocated knee cap?
- Surgery versus observation for people with abdominal injury
- Surgical approaches for dislocations of the neck bones
- Surgical versus conservative interventions for treating anterior cruciate ligament injuries
- Treatment of severe blunt pancreatic lesions in children
- Treatments for fingertip entrapment injuries in children
- Using ultrasound to aid diagnosis of patients with a 'blunt' injury to the abdomen
- WOUNDS (7)
- Dressings for the prevention of surgical site infection
- Honey as a topical treatment for acute and chronic wounds
- Immediate closure or delayed closure for treating traumatic wounds in the first 24 hours following injury
- Is there a best way to remove dead tissue from surgical wounds?
- Primary closure (immediate stitches) versus delayed closure (delayed stitches) or no closure (no stitches) for traumatic wounds due to mammalian bite
- The effects of water compared with other solutions for wound cleansing
- Tissue adhesives for closure of surgical skin incisions
- BLEEDING (5)
- UROLOGY AND KIDNEY DISEASES (17)
- KIDNEY DISEASES (5)
- Are anti-blood clotting drugs beneficial for people with chronic kidney disease?
- Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function
- Is sodium bicarbonate therapy helpful for people with acute kidney problems?
- Timing of initiation of kidney replacement therapy (dialysis) for acute kidney injury
- What are the benefits and harms of nonsteroidal anti-inflammatory drugs (NSAIDs) for treating acute renal colic?
- UROLOGY (12)
- Alpha-blockers for ureteral stones in adult patients with symptoms of stone disease
- Antibiotic prophylaxis for short-term catheter bladder drainage in adults
- Antibiotic treatment for asymptomatic bacteriuria
- Antibiotics for lower urinary tract infection in children
- Fluids and diuretics for treating acute ureteric colic
- Increased water intake for preventing urinary stones
- Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children
- Screening with urinary dipsticks for reducing morbidity and mortality
- Types of urethral catheters for management of short-term voiding problems in hospitalised adults
- Urinary alkalisation for uncomplicated urinary tract infections
- Urinary catheter policies for long-term bladder drainage
- Which route of short-term bladder drainage is best for adults in hospital?
- KIDNEY DISEASES (5)